4-甲基香豆素基-Β-D-吡喃半乳糖苷-6-硫酸 | 126938-14-5

• 物质功能分类: 生物化工 - 糖类化合物 - 单糖
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 中文名称: 4-甲基香豆素基-Β-D-吡喃半乳糖苷-6-硫酸
• 中文别名: 4-甲基香豆素基-β-D-吡喃半乳糖苷-6-硫酸
• 英文名称: 1-O-(4-methylumbellifer-7-yl)-β-D-galactose-6-sulfate
• 英文别名: [(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methyl-2-oxochromen-7-yl)oxyoxan-2-yl]methyl hydrogen sulfate
• CAS: 126938-14-5
• 化学式: C₁₆H₁₈O₁₁S
• 分子量: 418.378
• InChiKey: PAMBMLAUEGWIPT-DZQJYWQESA-N

物化性质

• 熔点：
  196-200°C
• 密度：
  1.676±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于水

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  177
• 氢给体数：
  4
• 氢受体数：
  11

安全信息

• WGK Germany：
  3

文献信息

• Diagnosis and treatment of multiple sulfatase deficiency and others using a formylglycine generating enzyme (FGE)
  申请人：Shire Human Genetic Therapies, Inc.

  公开号：EP2325301A1

  公开（公告）日：2011-05-25

  This invention relates to methods and compositions for the diagnosis and treatment of Multiple Sulfatase Deficiency (MSD) as well as other sulfatase deficiencies. More specifically, the invention relates to isolated molecules that modulate post-translational modifications on sulfatases. Such modifications are essential for proper sulfatase function.

  本发明涉及诊断和治疗多重硫酸酯酶缺乏症（MSD）以及其他硫酸酯酶缺乏症的方法和组合物。更具体地说，本发明涉及调节硫酸酯酶翻译后修饰的分离分子。这种修饰对硫酸酯酶的正常功能至关重要。
• Delivering enzyme using an injectable hydrogel depot
  申请人：Saint Louis University

  公开号：US11034950B2

  公开（公告）日：2021-06-15

  Compositions and methods for delivering enzymes in enzyme hydrogel formulations are disclosed. More particularly, the present disclosure relates to injectable enzyme hydrogel formulations and delivery of injectable enzyme hydrogel formulations. Also disclosed are methods for GALNS enzyme replacement therapy and lysosomal enzyme replacement therapy.

  本发明公开了在酶水凝胶制剂中输送酶的组合物和方法。更具体地说，本公开涉及可注射酶水凝胶制剂和可注射酶水凝胶制剂的递送。还公开了GALNS酶替代疗法和溶酶体酶替代疗法的方法。
• Diagnosis and treatment of multiple sulfatase deficiency and other sulfatase deficiencies
  申请人：Transkaryotic Therapies, Inc.

  公开号：US20040229250A1

  公开（公告）日：2004-11-18

  This invention relates to methods and compositions for the diagnosis and treatment of Multiple Sulfatase Deficiency (MSD) as well as other sulfatase deficiencies. More specifically, the invention relates to isolated molecules that modulate post-translational modifications on sulfatases. Such modifications are essential for proper sulfatase function.

  本发明涉及诊断和治疗多重硫酸酯酶缺乏症（MSD）以及其他硫酸酯酶缺乏症的方法和组合物。更具体地说，本发明涉及调节硫酸酯酶翻译后修饰的分离分子。这种修饰对硫酸酯酶的正常功能至关重要。
• DIAGNOSIS AND TREATMENT OF MULTIPLE SULFATASE DEFICIENCY AND OTHER USING A FORMYLGLYCINE GENERATING ENZYME (FGE)
  申请人：TRANSKARYOTIC THERAPIES, INC.

  公开号：EP1592786A2

  公开（公告）日：2005-11-09
• DIAGNOSIS AND TREATMENT OF MULTIPLE SULFATASE DEFICIENCY AND OTHER SULFATASE DEFICIENCIES USING A FORMYLGLYCINE GENERATING ENZYME (FGE)
  申请人：Shire Human Genetic Therapies, Inc.

  公开号：EP1592786B8

  公开（公告）日：2012-03-21