4,5-二氢-2-(1,2,3,4-四氢-1-萘基)-1H-咪唑单硝酸盐 | 118201-38-0

• 物质功能分类: 有机原料 - 杂环化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 中文名称: 4,5-二氢-2-(1,2,3,4-四氢-1-萘基)-1H-咪唑单硝酸盐
• 中文别名: 硝酸四氢唑啉；硝酸四氢萘咪唑；四氢唑啉硝酸盐
• 英文名称: Tetrahydrozoline nitrate
• 英文别名: nitric acid;2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole
• CAS: 118201-38-0
• 化学式: C13H17N3O3
• mdl: MFCD11973633
• 分子量: 263.29
• InChiKey: SVQFLMKSDLCPAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.24
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.461
• 拓扑面积：
  90.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Spray gel base and spray gel preparation using thereof
  申请人：Toko Yakuhin Kogyo Kabushiki Kaisha

  公开号：EP0391342A1

  公开（公告）日：1990-10-10

  A spray gel base having an excellent spread-stick property, which is prepared by thickening a 0.2 - 1.5 % by weight aqueous solution of carboxyvinyl polymer with a water-soluble basic substance, followed by adjusting the viscosity thereof with a viscosity adjustor within the range of 500 - 5,000 centipoise so that the particle size distribution of spray after spraying is over 80 % in the area of 20 - 100 µm and a spray gel preparation having an excellent spread-stick property, which is prepared by mixing an active medicament with said spray gel base.

  一种具有极佳铺展粘性的喷雾凝胶基剂，其制备方法是将重量百分比为 0.2 - 1.5 % 的羧基乙烯聚合物水溶液用水溶性碱性物质增稠，然后用粘度调节剂在 500 - 5,000 厘泊范围内调节其粘度，使喷洒后的喷雾粒度分布在 20 - 100 微米范围内超过 80 %；以及一种具有极佳铺展粘性的喷雾凝胶制剂，其制备方法是将活性药物与所述喷雾凝胶基剂混合。
• POLYSACCHARIDE-CONTAINING COMPOSITIONS AND USE THEREOF
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP1424081A1

  公开（公告）日：2004-06-02

  It is intended to prepare a composition which contains polysaccharide at a high concentration and yet remains in the state of a liquid having low viscosity to thereby provide drugs, eyedrops, foods, cosmetics, toiletry products having a novel texture or function. The composition in the state of a liquid having low viscosity is obtained by heating polysaccharide at a high concentration in a water-containing liquid and then cooling under applying a shear force, which enables the provision of the above-described drugs. The composition is usable as an aqueous drug vehicle which is free from gelling due to temperature changes during storage and easily applied without pouring and/or streaming down. Eyedrops containing agar have an effect of enhancing ocular drug penetration. Eyedrops containing particulate agar maintain a low viscosity and, achieve easy instillation and impart a favorable feel in instillation.

  其目的是制备一种含有高浓度多糖但仍保持低粘度液体状态的组合物，从而提供具有新颖质地或功能的药物、眼药水、食品、化妆品、盥洗用品。通过在含水液体中加热高浓度多糖，然后在施加剪切力的情况下冷却，可获得低粘度液体状态的组合物，从而提供上述药物。该组合物可用作水性药物载体，在储存过程中不会因温度变化而凝胶化，并且易于使用，不会倾倒和/或流下。含有琼脂的眼药水具有增强眼部药物渗透的效果。含有微粒琼脂的眼药水能保持较低的粘度，易于滴注，并在滴注时产生良好的感觉。
• REMEDY FOR CORNEAL ULCER
  申请人：Nishida, Teruo

  公开号：EP1604661A1

  公开（公告）日：2005-12-14

  The present invention provides a pharmaceutical agent capable of effectively treating corneal ulcer, more particularly, a therapeutic agent for corneal ulcer, which contains triptolide or a derivative thereof or a pharmaceutically acceptable salt thereof.

  本发明提供了一种能够有效治疗角膜溃疡的药剂，特别是一种角膜溃疡治疗剂，它含有曲普内酯或其衍生物或其药学上可接受的盐。
• Eyedrop comprising agar
  申请人：TORAY INDUSTRIES INC.

  公开号：EP2213308A1

  公开（公告）日：2010-08-04

  It is intended to prepare a composition which contains polysaccharide at a high concentration and yet remains in the state of a liquid having low viscosity to thereby provide drugs, eyedrops, foods, cosmetics, toiletry products having a novel texture or function. The composition in the state of a liquid having low viscosity is obtained by heating polysaccharide at a high concentration in a water-containing liquid and then cooling under applying a shear force, which enables the provision of the above-described drugs. The composition is usable as an aqueous drug vehicle which is free from gelling due to temperature changes during storage and easily applied without pouring and/or streaming down. Eyedrops containing agar have an effect of enhancing ocular drug penetration. Eyedrops containing particulate agar maintain a low viscosity and, achieve easy instillation and impart a favorable feel in instillation.

  其目的是制备一种含有高浓度多糖但仍保持低粘度液体状态的组合物，从而提供具有新颖质地或功能的药物、眼药水、食品、化妆品、盥洗用品。通过在含水液体中加热高浓度多糖，然后在施加剪切力的情况下冷却，可获得低粘度液体状态的组合物，从而提供上述药物。该组合物可用作水性药物载体，在储存过程中不会因温度变化而凝胶化，并且易于使用，不会倾倒和/或流下。含有琼脂的眼药水具有增强眼部药物渗透的效果。含有微粒琼脂的眼药水能保持较低的粘度，易于滴注，并在滴注时产生良好的感觉。
• AQUEOUS DISPERSION CONTAINING POLYSACCHARIDE PARTICULATE GEL AND METHOD FOR PRODUCING THE SAME
  申请人：Toray Industries, Inc.

  公开号：EP2241588A1

  公开（公告）日：2010-10-20

  Disclosed is an aqueous dispersion containing polysaccharide particulate gels, which is characterized by containing particulate gels substantially composed of a polysaccharide. The aqueous dispersion containing polysaccharide particulate gels is also characterized in that shapes of the particulate gels are maintained even after the particulate gels are heated for 30 minutes at 95°C in an aqueous medium. Namely, disclosed is an aqueous dispersion containing polysaccharide particulate gels, wherein the particulate gels are composed of a polysaccharide and have shapes that can be maintained even after 30-minute heating in an aqueous medium of 95°C.

  本发明公开了一种含有多糖微粒凝胶的水分散液，其特征在于含有主要由多糖组成的微粒凝胶。这种含有多糖微粒凝胶的水分散液的特征还在于，即使在水介质中将微粒凝胶在 95°C 的温度下加热 30 分钟，微粒凝胶的形状仍能保持不变。也就是说，本发明公开了一种含有多糖微粒凝胶的水分散液，其中的微粒凝胶由多糖组成，即使在 95°C 的水介质中加热 30 分钟后，其形状仍能保持不变。