1,7-bis(3-hydroxyphenyl)-4-methoxycarbonylhepta-1E,6E-dien-3,5-dione | 1255639-47-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 1,7-bis(3-hydroxyphenyl)-4-methoxycarbonylhepta-1E,6E-dien-3,5-dione
• 英文别名: methyl (E)-5-(3-hydroxyphenyl)-2-[(E)-3-(3-hydroxyphenyl)prop-2-enoyl]-3-oxopent-4-enoate
• CAS: 1255639-47-4
• 化学式: C₂₁H₁₈O₆
• 分子量: 366.37
• InChiKey: FIIYLKJCNGMCNQ-GFULKKFKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Inhibition of melanogenesis by chemically modified curcumins
  申请人：The Research Foundation for The State University of New York

  公开号：US10300000B2

  公开（公告）日：2019-05-28

  The present invention provides a method of treating a subject afflicted with hyperpigmentation or of lightening the skin tone of a subject comprising administering to the subject an amount of a compound having the structure: or a salt or ester thereof, so as to thereby treat the subject or lighten the skin tone of the subject.

  本发明提供了一种治疗受色素沉着困扰的受试者或淡化受试者肤色的方法，包括向受试者施用一定量的具有以下结构的化合物： 或其盐或酯，从而治疗受试者或淡化受试者的肤色。
• Curcumin analogues as zinc chelators and their uses
  申请人：Johnson Francis

  公开号：US10669227B2

  公开（公告）日：2020-06-02

  This invention provides a compound having the structure wherein α, β, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NFκ-B activation in a population of cells.

  本发明提供了一种具有以下结构的化合物 其中 α、β、X、Y 和 R1-R11 在本文中定义。本发明还提供了一种包含上述化合物的药物组合物、一种抑制基质金属蛋白酶（MMP）活性和/或水平的方法、一种抑制细胞群中细胞因子产生的方法、一种抑制细胞群中生长因子产生的方法以及一种抑制细胞群中 NFκ-B 激活的方法。
• [EN] CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES<br/>[FR] ANALOGUES DE CURCUMINE UTILISÉS EN TANT QUE CHÉLATEURS DU ZINC ET LEURS UTILISATIONS
  申请人：UNIV NEW YORK STATE RES FOUND

  公开号：WO2010132815A9

  公开（公告）日：2011-01-13
• CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES
  申请人：The Research Foundation for The State University of New York

  公开号：EP3206488B1

  公开（公告）日：2019-08-21
• CHEMICALLY MODIFIED CURCUMINS AS INHIBITORS OF ANTHRAX LETHAL FACTOR
  申请人：ANTONELLI Anthony

  公开号：US20150073021A1

  公开（公告）日：2015-03-12

  The present invention provides a method of inhibiting the binding of anthrax lethal factor with protective antigen comprising contacting the anthrax lethal factor with a compound having the structure: