methyl 6-hydroxy-1-(4-nitrophenyl)sulfonyl-3,4-dihydro-2H-quinoline-7-carboxylate | 1190202-60-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: methyl 6-hydroxy-1-(4-nitrophenyl)sulfonyl-3,4-dihydro-2H-quinoline-7-carboxylate
• CAS: 1190202-60-8
• 化学式: C₁₇H₁₆N₂O₇S
• 分子量: 392.389
• InChiKey: KYPIGXJZPAZGQX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  138
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  Methyl 2-methoxy-5-[(4-nitrophenyl)sulfonyl-pent-4-enylamino]furan-3-carboxylate 以 甲苯 为溶剂， 反应 20.0h， 以73%的产率得到methyl 6-hydroxy-1-(4-nitrophenyl)sulfonyl-3,4-dihydro-2H-quinoline-7-carboxylate
  参考文献：
  名称：

  Highly Substituted 2-Amido-furans From Rh(II)-Catalyzed Cyclopropenations of Ynamides

  摘要：

  Rh(II)-catalyzed cyclopropenations of ynamides are described. Although an actual amido-cyclopropene intermediate may not be involved, these reactions provide a facile entry to highly substituted 2-amido-turans, thereby formerly constituting a [3 + 2] cycloaddition. An application of these de novo 2-amido-turans in N-tethered intramolecular [4 + 2] cycloadditions is also illustrated, leading to dihydroindoles and tetrahydroquinolines.

  DOI：

  10.1021/ol901860b