(S)-1-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)ethanamine | 1233132-52-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (S)-1-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)ethanamine
• 英文别名: (1S)-1-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]ethanamine
• CAS: 1233132-52-9
• 化学式: C₂₀H₂₂N₂O₂
• 分子量: 322.407
• InChiKey: OMBNSIOGSOVWAW-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  61.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (1S)-N-[(1S)-1-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]ethyl]-1-phenylethanamine 在 palladium 10% on activated carbon 、 氢气 、 溶剂黄146 作用下， 以 甲醇 、 甲苯 为溶剂， 50.0 ℃ 、377.13 kPa 条件下， 以293 g的产率得到(S)-1-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)ethanamine
  参考文献：
  名称：

  Highly Diastereoselective Hydrogenation of Imines by a Bimetallic Pd−Cu Heterogeneous Catalyst

  摘要：

  An efficient and practical heterogeneous bimetallic Pd-Cu/C catalyst was identified as an alternative to Raney nickel for the highly diastereoselective hydrogenation of imines prepared from prochiral ketones and alpha-phenylethylamines. Chiral amines were obtained with diastereomeric excess (de) up to 94% using Pd-Cu/C, while conventional Pd-C catalysts afforded only 72% de. Optimization showed that a robust process required a palladium/copper ratio of 4:1. Evidence for the influence of catalyst pretreatment which may change the structure of the catalyst and/or metal oxidation states on the selectivity of the reaction is discussed. The bimetallic catalyst system provided consistent results on scale and performed reliably on a variety of substrates.

  DOI：

  10.1021/op1001325

文献信息

• Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
  申请人：Cheng T. Peter

  公开号：US20070015797A1

  公开（公告）日：2007-01-18

  Compounds are provided which have the structure wherein Q is C or N, A is O or S, Z is O or a bond, X is CH or N and R 1 , R 2 , R 2a , R 2b , R 2c , R 3 , Y, x, m, and n are as defined herein, which compounds are useful as antidiabetic, hypolipidemic, and antiobesity agents.

  提供了一些化合物，它们的结构如下：其中Q为C或N，A为O或S，Z为O或键，X为CH或N，R1、R2、R2a、R2b、R2c、R3、Y、x、m和n如此定义，这些化合物可用作抗糖尿病、降脂和抗肥胖药物。
• US7241780B2
  申请人：——

  公开号：US7241780B2

  公开（公告）日：2007-07-10
• US7579479B2
  申请人：——

  公开号：US7579479B2

  公开（公告）日：2009-08-25