| 260051-35-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 260051-35-2
• 化学式: C₂₆H₂₃NO₉
• 分子量: 493.47
• InChiKey: GKAFJTATTJEYBJ-OKAFBXPXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.53
• 重原子数：
  36.0
• 可旋转键数：
  7.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  134.43
• 氢给体数：
  1.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  在 sodium iodide 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Lectin-Mediated Drug Targeting: Discrimination of Carbohydrate-Mediated Cellular Uptake between Tumor and Liver Cells with Neoglycoconjugates Carrying Fucose Epitopes Regioselectively Modified in the 3-Position

  摘要：

  The circumvention of efficient "carbohydrate traps" in the liver is required for targeting glycoconjugates on tumor cells. As shown in the model system of bovine serum albumin (BSA) conjugates, the nature of R(1)-R(3) of the fucose epitope plays an important role in the discrimination of cellular uptake between tumor and liver cells as well as in the cytotoxic activity.

  DOI：

  10.1002/(sici)1521-3773(19991216)38:24<3680::aid-anie3680>3.0.co;2-9
• 作为产物：
  描述：

  2-硝基苯--Β-吡喃半乳糖苷 、 苯甲酰氯 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 以46%的产率得到
  参考文献：
  名称：

  Lectin-Mediated Drug Targeting: Discrimination of Carbohydrate-Mediated Cellular Uptake between Tumor and Liver Cells with Neoglycoconjugates Carrying Fucose Epitopes Regioselectively Modified in the 3-Position

  摘要：

  The circumvention of efficient "carbohydrate traps" in the liver is required for targeting glycoconjugates on tumor cells. As shown in the model system of bovine serum albumin (BSA) conjugates, the nature of R(1)-R(3) of the fucose epitope plays an important role in the discrimination of cellular uptake between tumor and liver cells as well as in the cytotoxic activity.

  DOI：

  10.1002/(sici)1521-3773(19991216)38:24<3680::aid-anie3680>3.0.co;2-9