4,6,6a,9b-四羟基-5a-(羟甲基)-1,8-二甲基-3-(1-甲基乙烯基)-7-羰基-1,2,3,4,4a,4b,5a,6,6a,7,9a,9b-十二氢苯并[7,8]薁并[5,6-b]噁丙烯-3-基(2E,4E)-癸-2,4-二烯酸酯 | 442-09-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 4,6,6a,9b-四羟基-5a-(羟甲基)-1,8-二甲基-3-(1-甲基乙烯基)-7-羰基-1,2,3,4,4a,4b,5a,6,6a,7,9a,9b-十二氢苯并[7,8]薁并[5,6-b]噁丙烯-3-基(2E,4E)-癸-2,4-二烯酸酯
• 中文别名: 6-氟-3-甲基喹啉-4-醇
• 英文名称: 6-Fluoro-3-methylquinolin-4-ol
• 英文别名: 6-fluoro-3-methyl-1H-quinolin-4-one
• CAS: 442-09-1
• 化学式: C₁₀H₈FNO
• 分子量: 177.17
• InChiKey: ONPXXNMNFDRPNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933499090

文献信息

• QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR
  申请人：Codd Ellen

  公开号：US20080300236A1

  公开（公告）日：2008-12-04

  This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to quinoline-derived amides that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.

  这项发明涉及辣椒素受体VR1配体。更具体地说，这项发明涉及喹啉衍生的酰胺，它们是VR1的有效拮抗剂或激动剂，可用于治疗和预防哺乳动物的炎症和其他疼痛症状。
• Prostaglandin Receptor EP2 Antagonists, Derivatives, Compositions, and Uses Related Thereto
  申请人：Emory University

  公开号：US20170042905A1

  公开（公告）日：2017-02-16

  The disclosure relates to Prostaglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing conditions and diseases in which EP2 receptor activation has a physiological role, such as but not limited to, brain injury, inflammatory diseases, neuroinflamation after a seizure, pain, endometriosis, cancer, rheumatoid arthritis, skin inflammation, vascular inflammation, colitis, and neurological disorders by administering a pharmaceutical composition comprising a compound disclosed herein to a subject in need thereof.
• US8394828B2
  申请人：——

  公开号：US8394828B2

  公开（公告）日：2013-03-12