2-(butylthiomethylene)-4-butanolide | 62527-61-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 2-(butylthiomethylene)-4-butanolide
• 英文别名: 3-[(Butylsulfanyl)methylidene]oxolan-2-one；3-(butylsulfanylmethylidene)oxolan-2-one
• CAS: 62527-61-1
• 化学式: C₉H₁₄O₂S
• 分子量: 186.275
• InChiKey: IBUZVVSASZHJKT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  51.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-(Butylsulfanyl-hydroxy-methyl)-3-chloro-dihydro-furan-2-one 在 二乙基亚磷酰氯 、 三乙胺 作用下， 反应 2.0h， 以74%的产率得到2-(butylthiomethylene)-4-butanolide
  参考文献：
  名称：

  摘要：

  Available hemiacetals and hemithioacetals of alpha-halo-beta-oxoaldehydes were reacted with phosphorochloridites in the presence of organic bases to obtain previously unknown alpha-heterosubstituted phosphites. It is found that the phosphites, depending on the nature of the carbonyl fragment and the heteroatom, enter intramolccular Perkow reaction or decompose to give unsaturated thioethers and chlorophosphate.

  DOI：

  10.1023/a:1015380909403

文献信息

• Substituted-hetero-cyclopentanones and cyclopentenones and derivatives
  申请人：Warner-Lambert Company

  公开号：US05066663A1

  公开（公告）日：1991-11-19

  Substituted-hetero-cyclopentanones and cyclopentenones and derivatives thereof are described, as well as methods for the preparation and pharmaceutical compositions of same, which are useful as centrally acting muscarinic agents and are useful as analgesic agents for the treatment of pain, as sleep aids and as agents for treating the symptoms of senile dementia, Alzheimer's disease, Huntington's chorea, tardive dyskinesia, hyperkinesia, mania, or similar conditions of cerebral insufficiency characterized by decreased cerebral acetylcholine production or release.

  本文描述了替代杂环戊酮和环戊烯酮及其衍生物，以及其制备方法和制备的药物组合物，其可用作中枢作用的毒蕈碱受体激动剂，并可用作镇痛剂治疗疼痛，作为助眠剂和作为治疗老年痴呆症、阿尔茨海默病、亨廷顿舞蹈症、迟发性运动障碍、过度运动、躁狂或类似的脑部衰竭症状的药物。这些药物的特点是减少了脑部乙酰胆碱产生或释放。
• ——
  作者：F. I. Guseinov、R. N. Burangulova

  DOI：10.1023/a:1015380909403

  日期：——

  Available hemiacetals and hemithioacetals of alpha-halo-beta-oxoaldehydes were reacted with phosphorochloridites in the presence of organic bases to obtain previously unknown alpha-heterosubstituted phosphites. It is found that the phosphites, depending on the nature of the carbonyl fragment and the heteroatom, enter intramolccular Perkow reaction or decompose to give unsaturated thioethers and chlorophosphate.