1-(4-methoxy-2'-methyl-biphen-2-yl)-ethanone | 841299-52-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-methoxy-2'-methyl-biphen-2-yl)-ethanone
• 英文别名: 1-[5-methoxy-2-(2-methylphenyl)phenyl]ethanone
• CAS: 841299-52-3
• 化学式: C₁₆H₁₆O₂
• 分子量: 240.302
• InChiKey: HZFYBHDAAWTEQQ-UHFFFAOYSA-N

物化性质

• 沸点：
  366.2±37.0 °C(Predicted)
• 密度：
  1.060±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(4-methoxy-2'-methyl-biphen-2-yl)-ethanone 在 sodium tetrahydroborate 、 碘 作用下， 以 xylene 为溶剂， 生成 4-Methoxy-2'-methyl-2-vinyl-biphenyl
  参考文献：
  名称：

  摘要：

  9,10-Dihydrophenanthrenes and phenanthrenes, mimics of natural compounds with strong antialgal activity, have been synthesized through cross-coupling of 1-(2-iodo-5-methoxy)-phenylethanol with variously substituted iodobenzenes. The synthetic compounds, bearing a hydroxyl or a methoxyl group at C-2 and a methyl in the C ring, were tested against the green alga Selenastrum capricornutum. All compounds, except 2-methoxy-7-methylphenanthrene, caused inhibition of algal growth by more than 70% at 10(-4) M, and many of them retained this strong activity at 10(-5) M.

  DOI：

  10.1023/a:1005463802388
• 作为产物：
  描述：

  3-甲氧基苯乙酮 在 碘 、 silver trifluoroacetate 、 三苯基膦 、 nickel dichloride 、 锌 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 70.0h， 生成 1-(4-methoxy-2'-methyl-biphen-2-yl)-ethanone
  参考文献：
  名称：

  摘要：

  9,10-Dihydrophenanthrenes and phenanthrenes, mimics of natural compounds with strong antialgal activity, have been synthesized through cross-coupling of 1-(2-iodo-5-methoxy)-phenylethanol with variously substituted iodobenzenes. The synthetic compounds, bearing a hydroxyl or a methoxyl group at C-2 and a methyl in the C ring, were tested against the green alga Selenastrum capricornutum. All compounds, except 2-methoxy-7-methylphenanthrene, caused inhibition of algal growth by more than 70% at 10(-4) M, and many of them retained this strong activity at 10(-5) M.

  DOI：

  10.1023/a:1005463802388

文献信息

• Bicyclic heteroaryl derivatives
  申请人：Schmitz Ulrich Franz

  公开号：US20050187390A1

  公开（公告）日：2005-08-25

  Disclosed are compounds, compositions and methods for treating Flaviviridae family virus infections.

  本发明涉及用于治疗黄病毒科病毒感染的化合物、组合物和方法。
• BICYCLIC HETEROARYL DERIVATIVES
  申请人：Schmitz Franz Ulrich

  公开号：US20090081165A1

  公开（公告）日：2009-03-26

  Disclosed are compounds, compositions and methods for treating Flaviviridae family virus infections.

  本发明揭示了用于治疗黄病毒科病毒感染的化合物、组合物和方法。