4-Bromo-2-<(2-diethylaminoethyl)ethylaminomethyl>-6-formylphenol | 138537-73-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Bromo-2-<(2-diethylaminoethyl)ethylaminomethyl>-6-formylphenol
• 英文别名: 5-Bromo-3-[[2-(diethylamino)ethyl-ethylamino]methyl]-2-hydroxybenzaldehyde
• CAS: 138537-73-2
• 化学式: C₁₆H₂₅BrN₂O₂
• 分子量: 357.291
• InChiKey: OXRNAWZRGXNXFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-Bromo-2-<(2-diethylaminoethyl)ethylaminomethyl>-6-formylphenol 、 聚甘氨酸 生成 {[1-(5-Bromo-3-{[(2-diethylamino-ethyl)-ethyl-amino]-methyl}-2-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-acetic acid
  参考文献：
  名称：

  Anion-Dependent Substitution of Zinc by Magnesium in Mononuclear Schiff Base Complexes

  摘要：

  DOI：

  10.1002/1099-0682(200209)2002:9<2276::aid-ejic2276>3.0.co;2-b
• 作为产物：
  描述：

  N,N,N'-三乙基乙二胺 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 87.0h， 生成 4-Bromo-2-<(2-diethylaminoethyl)ethylaminomethyl>-6-formylphenol
  参考文献：
  名称：

  带有氮和氧供体原子的不对称双核配体的合成

  摘要：

  描述了带有氮和氧供体原子的不对称双核配体的合成。功能化水杨醛衍生物与伯胺的席夫碱缩合产生不对称的不饱和配体，而与仲胺的缩合随后用硼氢化钠原位还原亚胺类，导致形成不对称的饱和配体。后者也通过4-氯间苯二酚的曼尼希串联反应制备。

  DOI：

  10.1016/0040-4020(96)00222-0

文献信息

• Unsymmetric dicopper(II) complexes of dinucleating ligands bearing chemically distinct co-ordination environments
  作者：Jonathan D. Crane、David E. Fenton、Jean Marc Latour、Arnold J. Smith

  DOI：10.1039/dt9910002979

  日期：——

  Dicopper(II) complexes of unsymmetrical dinucleating Schiff-base ligands bearing chemically distinct co-ordination sites have been prepared and their properties studied. The ligands were derived from the condensation of 4-bromo-2-formyl-6-(4-methylpiperazin-1-ylmethyl)phenol and 4-bromo-2-[(2-diethylaminoethyl)ethylaminomethyl]-6-formylphenol with 2-(aminomethyl)pyridine, 2-(2-aminoethyl)pyridine,

  制备了具有化学上不同配位位点的不对称双核席夫碱配体的Dicopper（II）配合物，并对其性质进行了研究。所述配体衍生自4-溴-2-甲酰基-6-（4-甲基哌嗪-1-基甲基）苯酚和4-溴-2-[（（2-二乙基氨基乙基）乙基氨基甲基] -6-甲酰基苯酚与2-的缩合。 （氨基甲基）吡啶，2-（2-氨基乙基）吡啶和2-（氨基甲基）-4-硝基苯酚。
• Copper coordination to the aldehyde and hemiacetal form of 4-bromo-2-[(2-diethylaminoethyl)ethylaminomethyl]-6-formylphenol: Synthesis and structure of [Cu(H2L)2(X)2] X2·nH2O () and [Cu(L′)]2·2CH3OH
  作者：Andrea Erxleben

  DOI：10.1016/j.ica.2008.02.016

  日期：2009.2

  The coordination behaviour of Cu2+ towards 4-bromo-2-[(2-diethylaminoethyl)ethyl-aminomethyl]-6-formylphenol(HL) having phenolate, amine and aldehyde donor sites has been studied. In aqueous, weakly acidic solution Cu2+ coordinates to the phenolate and aldehyde oxygen giving rise to the complexes [Cu(H2L)(2)X-2]X-2 (X = NO3- (1a) and CIO4- (1b)), while in alkaline solution a complex of composition [CuL2] (2) is formed. In methanol, the aldehyde groups in 1 and 2 suffer nucleophilic attack from the solvent resulting in the formation of the hemiacetal form of the ligand and in the isolation of [Cu(L')](2) center dot 2CH(3)OH (3). X-ray structures of 1a, 1b and 3 are reported, the latter featuring a rare example of a coordinated methyl-hemiacetal. (C) 2008 Elsevier B. V. All rights reserved.