N,N,N',N'-tetraoctyltetrahydrofuran-2,5-dicarboxamide | 1332306-04-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环氧化物
• 英文名称: N,N,N',N'-tetraoctyltetrahydrofuran-2,5-dicarboxamide
• CAS: 1332306-04-3
• 化学式: C₃₈H₇₄N₂O₃
• 分子量: 607.017
• InChiKey: OGYFOYRTVGOBRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.63
• 重原子数：
  43.0
• 可旋转键数：
  30.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  49.85
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  2,5-呋喃二甲酸 在 草酰氯 、 palladium 10% on activated carbon 、 氢气 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 20.0 ℃ 、800.01 kPa 条件下， 生成 N,N,N',N'-tetraoctyltetrahydrofuran-2,5-dicarboxamide
  参考文献：
  名称：

  Synthesis and Am/Eu extraction of novel TODGA derivatives

  摘要：

  Various ligands with structural modifications of the N,N,N',N'-tetraoctyl-3-oxapentanediamide (TODGA) skeleton were synthesised in good yields. These modifications include (1) the increase in chain length from one carbon to two carbons between the central ether oxygen atom and the amide moieties, (2) the addition of substituents on the carbon between the central oxygen atom and the amide moieties on one and both sides of the central oxygen, (3) the replacement of the central oxygen by a (substituted) nitrogen atom and (4) synthesis of a rigidified glycolamide. The effect of the structural modifications on their extraction behaviours toward Am(III) and Eu(III) at various nitric acid concentrations was studied. In most of the cases, the extraction does not exceed that of TODGA in the entire acidity range of 0.001-4mol/l HNO3. The extraction behaviour of monomethyl-TODGA derivative 10a resembles that of TODGA at high nitric acid concentrations. However, at lower acidities, its D values are much lower, which is beneficial for possible back-extraction steps. The aza-tripodal ligands 18a,b show reverse extraction properties compared to TODGA as far as the pH influence is concerned: at pH 2, the DAm values are 49.9 and 3.1, the DEu values are 5.9 and 0.2, and the SAm/Eu values are 8 and 11, respectively.

  DOI：

  10.1080/10610278.2010.506553