3-{4-[(1H-Imidazol-1-yl)methyl]phenyl}prop-2-en-1-ol | 123853-55-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂醇
• 英文名称: 3-{4-[(1H-Imidazol-1-yl)methyl]phenyl}prop-2-en-1-ol
• 英文别名: 3-[4-(imidazol-1-ylmethyl)phenyl]prop-2-en-1-ol
• CAS: 123853-55-4
• 化学式: C₁₃H₁₄N₂O
• 分子量: 214.26
• InChiKey: LSGKQNNFEGZTQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  38
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• 1,4-Dihydropyridine derivatives
  申请人：FUJIREBIO INC.

  公开号：EP0320984A2

  公开（公告）日：1989-06-21

  1,4-Dihydropyridine derivatives of the formula (I) having vasodilative activity and inhibitory activity on platelet aggregation: wherein Ar¹ represents an aromatic hydrocarbon group or heterocyclic group which may have at least one substituent; R¹ represents a hydrocarbon group which may have at least one substituent; A and B each represent a hydrocarbon group which may have at least one substituent, in which any of the carbon atoms in the main chain thereof may be replaced by a nitrogen atom or an oxygen atom; Ar² represents an aromatic hydrocarbon group or heterocyclic group; Ar³ represents a heterocyclic group which may have at least one substituent; and n is 0 or 1.

  具有血管扩张活性和血小板聚集抑制活性的式 (I) 1,4-二氢吡啶衍生物： 其中 Ar¹ 代表芳香烃基团或杂环基团，可具有至少一个取代基；R¹ 代表烃基团，可具有至少一个取代基；A 和 B 各自代表烃基团，可具有至少一个取代基，其中主链上的任一碳原子可被氮原子或氧原子取代；Ar² 代表芳香烃基团或杂环基团；Ar³ 代表杂环基团，可具有至少一个取代基；n 为 0 或 1。
• 1,4-dihydropyridine derivatives
  申请人：FUJIREBIO INC.

  公开号：EP0400660A1

  公开（公告）日：1990-12-05

  1,4-Dihydropyridine derivatives of formula (I): wherein Ar1 and Ar2 each represent an unsubstituted or substituted aromatic hydrocarbon or aromatic heterocyclic group; and R1 represents -C02R2, -SO2R3, -COR4, -CON(R5)2, -CN or -NO2 in which R2 is hydrogen, a straight chain, branched chain or cyclic saturated hydrocarbon group, which may have a substituent or a straight chain, branched chain or cyclic unsaturated hydrocarbon group having 2 to 10 carbon atoms, which may have a substituent, R3 is an alkyl group having 1 to 4 carbon atoms, R4 is an alkyl group having 1 to 4 carbon atoms or a phenyl group; and R5 is an alkyl group having 1 to 4 carbon atoms.

  式(I)的 1,4-二氢吡啶衍生物： 其中 Ar1 和 Ar2 各自代表未取代或取代的芳香烃或芳香杂环基团； 和 R1 代表-C02R2、-SO2R3、-COR4、-CON(R5)2、-CN 或 -NO2，其中 R2 是氢、直链、支链或环状饱和烃基（可有取代基）或具有 2 至 10 个碳原子的直链、支链或环状不饱和烃基（可有取代基），R3 是具有 1 至 4 个碳原子的烷基，R4 是具有 1 至 4 个碳原子的烷基或苯基； R5 是具有 1 至 4 个碳原子的烷基。
• Optical active 1,4-dihydropyridine derivates
  申请人：FUJIREBIO INC.

  公开号：EP0403957A2

  公开（公告）日：1990-12-27

  Optical active 1,4-dihydropyridine derivatives of formula: wherein Ar¹ represents an aromatic hydrocarbon group or an aromatic heteromonocyclic or heterobicyclic group containing therein 1 to 3 atoms selected from the group consisting of oxygen, sulfur and nitrogen; R¹ represents a hydrocarbon group which may have one or more substituents; A represents (i) a straight chain or branched chain unsaturated hydrocarbon group, (ii) a cyclic unsaturated hydrocarbon group, or (iii) a group selected from the group consisting of -R-O-N=CH-, -R-N=N-, -R-CH=N- and -R-N=CH-, in which R is an alkylene group having 1 to 6 carbon atoms; B represents an alkylene or alkenylene group having 1 to 3 carbon atoms, which may have a substituent; Ar² represents an aromatic hydrocarbon group or a heterocyclic group; Ar³ represents a heterocyclic group which may have one or more substituents; and n is 0 or 1, and * indicates an optically active cite.

  式中具有光学活性的 1,4-二氢吡啶衍生物： 其中 Ar¹ 代表芳香烃基团或芳香杂单环基团或杂环基团，其中包含 1 至 3 个原子，这些原子选自由氧、硫和氮组成的组；R¹ 代表烃基团，可以有一个或多个取代基；A 代表(i)直链或支链不饱和烃基，(ii)环状不饱和烃基，或(iii)选自-R-O-N=CH-、-R-N=N-、-R-CH=N-和-R-N=CH-的基团，其中 R 是具有 1 至 6 个碳原子的亚烷基；Ar² 代表芳香烃基团或杂环基团；Ar³ 代表杂环基团，可带有一个或多个取代基；n 为 0 或 1，* 表示光学活性引物。
• Piperidine derivatives and their use as antiarrhythmic agents
  申请人：Ajinomoto Co., Inc.

  公开号：EP0479601B1

  公开（公告）日：1999-12-15
• JPH0441478A
  申请人：——

  公开号：JPH0441478A

  公开（公告）日：1992-02-12