2-[(E)-3-(1,3-benzodioxol-5-yl)prop-2-enoyl]-5-(2,4,6-trimethylphenyl)cyclohexane-1,3-dione | 1309370-56-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 2-[(E)-3-(1,3-benzodioxol-5-yl)prop-2-enoyl]-5-(2,4,6-trimethylphenyl)cyclohexane-1,3-dione
• CAS: 1309370-56-6
• 化学式: C₂₅H₂₄O₅
• 分子量: 404.463
• InChiKey: KSAUCFYOVLJUAI-GQCTYLIASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  69.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-[(E)-3-(1,3-benzodioxol-5-yl)prop-2-enoyl]-5-(2,4,6-trimethylphenyl)cyclohexane-1,3-dione 在 potassium carbonate 作用下， 以 氯仿 、 甲苯 为溶剂， 生成 2-[(E)-3-(1,3-benzodioxol-5-yl)prop-2-enoyl]-3-(4-methylphenylamino)-5-(2,4,6-trimethylphenyl)cyclohex-2-en-1-one
  参考文献：
  名称：

  Synthesis of exo- and endocyclic enamino derivatives of 2-(3-arylprop-2-enoyl)cyclohexane-1,3-diones

  摘要：

  Condensation of 2-acetylcyclohexane-1,3-diones with aromatic aldehydes in the presence of piperidine, pyrrolidine, hexamethyleneimine, or morpholine gave the corresponding 2-(3-arylprop-2-enoyl)cyclohexane-1,3-diones as the major products and 2-[3-aryl-1-cycloalkylaminoprop-2-en-1-ylidene]cyclohexane1,3-diones as minor ones. Endocyclic enamino derivatives were synthesized in two steps through enol methyl ethers which reacted with amines. Endocyclic enamino derivatives of 2-(3-arylprop-2-enoyl) cyclohexane-1,3-diones containing an aryl group on the nitrogen atom readily underwent cyclization to 1,2,3,4,5,6,7,8-octa-hydroquinoline-4,5-dione derivatives.

  DOI：

  10.1134/s1070428011030018
• 作为产物：
  描述：

  哌啶 、 胡椒醛 、 2-acetyl-5-mesitylcyclohexane-1,3-dione 以 甲苯 为溶剂， 以74%的产率得到2-[(E)-3-(1,3-benzodioxol-5-yl)prop-2-enoyl]-5-(2,4,6-trimethylphenyl)cyclohexane-1,3-dione
  参考文献：
  名称：

  Synthesis of exo- and endocyclic enamino derivatives of 2-(3-arylprop-2-enoyl)cyclohexane-1,3-diones

  摘要：

  Condensation of 2-acetylcyclohexane-1,3-diones with aromatic aldehydes in the presence of piperidine, pyrrolidine, hexamethyleneimine, or morpholine gave the corresponding 2-(3-arylprop-2-enoyl)cyclohexane-1,3-diones as the major products and 2-[3-aryl-1-cycloalkylaminoprop-2-en-1-ylidene]cyclohexane1,3-diones as minor ones. Endocyclic enamino derivatives were synthesized in two steps through enol methyl ethers which reacted with amines. Endocyclic enamino derivatives of 2-(3-arylprop-2-enoyl) cyclohexane-1,3-diones containing an aryl group on the nitrogen atom readily underwent cyclization to 1,2,3,4,5,6,7,8-octa-hydroquinoline-4,5-dione derivatives.

  DOI：

  10.1134/s1070428011030018