(butyl-methyl-phenylsilyl)-phenylmethanone | 138996-69-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (butyl-methyl-phenylsilyl)-phenylmethanone
• CAS: 138996-69-7
• 化学式: C₁₈H₂₂OSi
• 分子量: 282.458
• InChiKey: HIYGSULUGOHILY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.19
• 重原子数：
  20.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  17.07
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  甲基溴化镁 、 (butyl-methyl-phenylsilyl)-phenylmethanone 以 乙醚 为溶剂， 以98%的产率得到1-(butyl-methyl-phenylsilyl)-1-phenylethanol
  参考文献：
  名称：

  1,2-diastereoselection induced by chiral silicon in the addition of Grignard reagents to acylsilanes

  摘要：

  The reaction of acylsilanes 1 with Grignard reagents gives the diastereomeric alpha-hydroxysilanes 3. The level of asymmetric induction depends on the nature of R1 and R2. Good results were obtained for R1 = t-Bu, R2 = Me and R1 = alpha-Napht, R2 = Ph. Subsequent desilylation occurs with predominant inversion of configuration at carbon.

  DOI：

  10.1016/s0040-4039(00)93607-4
• 作为产物：
  描述：

  Butyl-methyl-phenyl-(2-phenyl-[1,3]dithian-2-yl)-silane 在 无水碳酸镉 、 mercury dichloride 作用下， 生成 (butyl-methyl-phenylsilyl)-phenylmethanone
  参考文献：
  名称：

  1,2-diastereoselection induced by chiral silicon in the addition of Grignard reagents to acylsilanes

  摘要：

  The reaction of acylsilanes 1 with Grignard reagents gives the diastereomeric alpha-hydroxysilanes 3. The level of asymmetric induction depends on the nature of R1 and R2. Good results were obtained for R1 = t-Bu, R2 = Me and R1 = alpha-Napht, R2 = Ph. Subsequent desilylation occurs with predominant inversion of configuration at carbon.

  DOI：

  10.1016/s0040-4039(00)93607-4