bis(N(1)-methylundecanal thiosemicarbazonate)nickel(II) | 959773-18-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: bis(N(1)-methylundecanal thiosemicarbazonate)nickel(II)
• CAS: 959773-18-3
• 化学式: C₂₆H₅₂N₆NiS₂
• 分子量: 571.561
• InChiKey: VDWYOAQITKIQEJ-UHFFFAOYSA-L

反应信息

• 作为产物：
  描述：

  N(1)-methylundecanal thiosemicarbazone 、 nickel(II) acetate tetrahydrate 以 甲醇 为溶剂， 以75%的产率得到bis(N(1)-methylundecanal thiosemicarbazonate)nickel(II)
  参考文献：
  名称：

  Synthesis, characterization, crystal structure and antiproliferative in vitro activity of long-chain aliphatic thiosemicarbazones and their Ni(II) complexes

  摘要：

  In the course of a research on metal-based compounds active on white blood cell cancers (leukemia, lymphoma and myeloma) nine aliphatic thiosemicarbazones and their nickel complexes have been synthesized with the aim to test their effect on histiocytic lymphoma U937 cell proliferation. All compounds were characterized by elemental, IR and NMR spectra analyses and for five of the complexes also by X-ray crystallography diffraction analysis. Heptanal thiosemicarbazone and the corresponding nickel complex were chosen after a solubility/stability test to carry out preliminary experiments in vitro on human leukemia cell line U937. The complex possesses a remarkable biological activity in inhibiting cell growth and in inducing apoptosis. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2007.07.014