| 947382-73-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 947382-73-2
• 化学式: C₃₆H₄₅N₃O₈
• 分子量: 647.769
• InChiKey: PNKWHDYMHDBUHM-DJUCWIQWSA-N

反应信息

• 作为反应物：
  描述：

  在 palladium on activated charcoal 氢气 作用下， 以 甲醇 、 乙酸乙酯 为溶剂， 25.0 ℃ 、101.33 kPa 条件下， 反应 7.0h， 以53%的产率得到(2S,3R)-2-acetamido-3-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-N-methylbutanamide
  参考文献：
  名称：

  Serine versus Threonine Glycosylation:  The Methyl Group Causes a Drastic Alteration on the Carbohydrate Orientation and on the Surrounding Water Shell

  摘要：

  Different behavior has been observed for the psi torsion angle of the glycosidic linkages of d-GalNAc-Ser and d-GalNAc-Thr motifs, allowing the carbohydrate moiety to adopt a completely different orientation. In addition, the fact that the water pockets found in alpha-d-GalNAc-Thr differ from those obtained for its serine analogue could be related to the different capability that the two model glycopeptides have to structure the surrounding water. This fact could have important biological inferences (i.e., antifreeze activity).

  DOI：

  10.1021/ja072181b
• 作为产物：
  描述：

  在 Ni Raney (T₄) 吡啶 、 N-碘代丁二酰亚胺 、 氢气 、 三氟乙酸 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 25.0 ℃ 、101.33 kPa 条件下， 反应 36.0h， 生成
  参考文献：
  名称：

  Serine versus Threonine Glycosylation:  The Methyl Group Causes a Drastic Alteration on the Carbohydrate Orientation and on the Surrounding Water Shell

  摘要：

  Different behavior has been observed for the psi torsion angle of the glycosidic linkages of d-GalNAc-Ser and d-GalNAc-Thr motifs, allowing the carbohydrate moiety to adopt a completely different orientation. In addition, the fact that the water pockets found in alpha-d-GalNAc-Thr differ from those obtained for its serine analogue could be related to the different capability that the two model glycopeptides have to structure the surrounding water. This fact could have important biological inferences (i.e., antifreeze activity).

  DOI：

  10.1021/ja072181b