1,2,3-tris-O-acetyl-D-mannopyranoside | 68791-12-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,2,3-tris-O-acetyl-D-mannopyranoside
• 英文别名: [(2R,3S,4S,5R,6R)-2,3-diacetyloxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl] acetate
• CAS: 68791-12-8
• 化学式: C₁₂H₁₈O₉
• 分子量: 306.27
• InChiKey: GNYSCNOUXJBUSG-GCHJQGSQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  129
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  4,6-O-benzylidene-1,2,3-tris-O-acetyl-D-mannopyranoside 在 溶剂黄146 作用下， 以 水 为溶剂， 生成 1,2,3-tris-O-acetyl-D-mannopyranoside 、 1,2,3-tris-O-acetyl-D-mannopyranoside
  参考文献：
  名称：

  Conformational study of the hydroxymethyl group in α-d-mannose derivatives

  摘要：

  A study of the dependence of the hydroxymethyl group in a-D-mannose derivatives on the aglycon and its absolute configuration was performed by means of circular dichroism (CD) and NMR data. Depending mainly on the aglycon present, the gg or the gt rotamer was the most populated, the tg rotamer having a small population. In addition, the study showed a correlation between the rotational populations and the aglycon, the population of the gt rotamer increasing as the pK(a) of the bonded alcohol (aglycon) increased. Furthermore, the results revealed a strong dependence on the absolute configuration of the aglycon and point to the stereoelectronic exo-anomeric effect being responsible for these rotational dependencies besides nonbonding interactions. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(03)00623-2

文献信息

• MANNOSE DERIVATIVES FOR TREATING BACTERIAL INFECTIONS
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：US20140243283A1

  公开（公告）日：2014-08-28

  The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula I: The invention also provides pharmaceutically acceptable compositions containing the compounds and methods of using the compositions in the treatment of bacteria infections. Finally, the invention provides processes for making compounds of the invention.

  本发明涉及用于治疗或预防细菌感染的化合物。这些化合物的化学式为I：本发明还提供包含该化合物的药学上可接受的组合物，并提供使用该组合物治疗细菌感染的方法。最后，本发明提供了制备该化合物的方法。
• Mannose Derivatives for Treating Bacterial Infections
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：US20160235775A1

  公开（公告）日：2016-08-18

  The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula I: The invention also provides pharmaceutically acceptable compositions containing the compounds and methods of using the compositions in the treatment of bacteria infections. Finally, the invention provides processes for making compounds of the invention.

  本发明涉及用于治疗或预防细菌感染的化合物。这些化合物的化学式为I：本发明还提供了含有这些化合物的药学上可接受的组合物以及使用这些组合物治疗细菌感染的方法。最后，本发明还提供了制备本发明化合物的方法。
• SACCHARIDE CONJUGATES
  申请人：ARIZONA BOARD OF REGENTS, for and on behalf of ARIZONA STATE UNIVERSITY

  公开号：US20160038615A1

  公开（公告）日：2016-02-11

  This invention relates to compounds comprising a saccharide conjugated to an imaging agent or a reporter group, compositions comprising them and methods of using them. Specifically BLM-disaccharide and BLM-monosaccharide conjugates containing different linker groups and an imaging agent or a reporter group are provided for the targeting and imaging of tumors.

  本发明涉及包含糖链与成像剂或报告基团偶联的化合物、包含它们的组合物以及使用它们的方法。具体提供了含有不同连接基团和成像剂或报告基团的BLM-双糖和BLM-单糖共轭物，用于靶向和成像肿瘤。
• SUGAR-LINKER-DRUG CONJUGATES
  申请人：ARIZONA BOARD OF REGENTS, FOR AND ON BEHALF OF, ARIZONA STATE UNIVERSITY

  公开号：US20160045611A1

  公开（公告）日：2016-02-18

  The present disclosure relates to sugar-linker-drug conjugates, of the formula [A-B-]n-L-D, wherein A is a saccharide; B is a spacer, n is an integer selected from 1 to 3; L is a linker group and D is a drug having a chemically reactive functional group selected from the group consisting of a primary or secondary amine, hydroxyl, sulfhydryl, carboxyl, aldehyde and ketone. Pharmaceutical compositions comprising the conjugates and methods of using them are also provided.

  本公开涉及糖链连接药物偶联物，其化学式为[A-B-]n-L-D，其中A为糖类；B为间隔物，n为从1到3选择的整数；L为连接基团，D为具有化学反应性官能团的药物，所述官能团选择自一级或二级胺、羟基、硫醇、羧基、醛和酮的群组。还提供了包含该偶联物的制药组合物以及使用它们的方法。