7-oxoundecanal | 1338916-21-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 7-oxoundecanal
• CAS: 1338916-21-4
• 化学式: C₁₁H₂₀O₂
• 分子量: 184.279
• InChiKey: CEBWSXPIVBXXDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7-oxoundecanal 在 copper(l) iodide 、 全氟丁基磺酰氟 、 二异丙胺 、 三苯基膦 、 (叔丁基亚氨基)三(吡咯烷)膦 、 palladium dichloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 11-cyclopentenylundec-10-yn-5-one
  参考文献：
  名称：

  Convenient synthesis of non-conjugated alkynyl ketones from keto aldehydes by a chemoselective one-pot nonaflation—base catalyzed elimination sequence

  摘要：

  Keto aldehydes were selectively converted to non-conjugated alkynyl ketones possessing an unsubstituted alkyne terminus using one-pot nonaflation-base catalyzed elimination reaction sequences. Consecutive one-pot nonaflation of keto aldehydes with perfluorobutane-l-sulfonyl fluoride and elimination of the nonaflyl group using the P(1) phosphazene base resulted in the formation of a terminal C C triple bond with the keto group remaining intact. Careful optimization of the reaction conditions enabled a highly chemoselective conversion of the aldehyde function in the presence of unprotected keto groups exploiting a minor difference in acidity of their alpha-hydrogen atoms. Scope and limitations of the protocol as well as possible implementation of these substrates in Sonogashira coupling were explored. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.05.095
• 作为产物：
  描述：

  1-n-butylcyclohept-1-ene 在 臭氧 、 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 以72%的产率得到7-oxoundecanal
  参考文献：
  名称：

  Convenient synthesis of non-conjugated alkynyl ketones from keto aldehydes by a chemoselective one-pot nonaflation—base catalyzed elimination sequence

  摘要：

  Keto aldehydes were selectively converted to non-conjugated alkynyl ketones possessing an unsubstituted alkyne terminus using one-pot nonaflation-base catalyzed elimination reaction sequences. Consecutive one-pot nonaflation of keto aldehydes with perfluorobutane-l-sulfonyl fluoride and elimination of the nonaflyl group using the P(1) phosphazene base resulted in the formation of a terminal C C triple bond with the keto group remaining intact. Careful optimization of the reaction conditions enabled a highly chemoselective conversion of the aldehyde function in the presence of unprotected keto groups exploiting a minor difference in acidity of their alpha-hydrogen atoms. Scope and limitations of the protocol as well as possible implementation of these substrates in Sonogashira coupling were explored. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.05.095

文献信息

• [EN] SPIRO-LACTAM AND BIS-SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF<br/>[FR] MODULATEURS SPIRO-LACTAMES ET BIS-SPIRO-LACTAMES DES RÉCEPTEURS NMDA ET LEURS UTILISATIONS
  申请人：APTINYX INC

  公开号：WO2018026792A1

  公开（公告）日：2018-02-08

  Disclosed are compounds having potency in the modulation of NMDA receptor activity. Such compounds can be used in the treatment of conditions such as depression and related disorders. Orally delivered formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.

  揭示了具有调节NMDA受体活性潜力的化合物。这些化合物可用于治疗
• Spiro-lactam and bis-spiro-lactam NMDA receptor modulators and uses thereof
  申请人：Aptinyx Inc.

  公开号：US11028095B2

  公开（公告）日：2021-06-08

  Disclosed are compounds having potency in the modulation of NMDA receptor activity. Such compounds can be used in the treatment of conditions such as depression and related disorders. Orally delivered formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.

  所公开的化合物具有调节 NMDA 受体活性的功效。此类化合物可用于治疗抑郁症及相关疾病。此外，还公开了口服制剂和其他药学上可接受的化合物给药形式，包括静脉注射制剂。
• SPIRO-LACTAM AND BIS-SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF
  申请人：Aptinyx Inc.

  公开号：EP3490994A1

  公开（公告）日：2019-06-05