1,1'-diethyl-2,2'-dicarbocyanine | 802568-48-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1,1'-diethyl-2,2'-dicarbocyanine
• 英文别名: (2E)-1-ethyl-2-[5-(1-ethylquinolin-1-ium-2-yl)penta-2,4-dienylidene]quinoline
• CAS: 802568-48-5
• 化学式: C₂₇H₂₇N₂
• 分子量: 379.525
• InChiKey: HUKKJPBJMKANKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  7.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Surface Grafted Conjugated Polymers
  申请人：Whitten David G.

  公开号：US20110159605A1

  公开（公告）日：2011-06-30

  A surface grafted conjugated polyelectrolyte (CPE) is formed by coupling a CPE by a coupling moiety to the surface of a substrate. The substrate can be of any shape and size, and for many uses of the surface grafted CPE, it is advantageous that the substrate is a nanoparticle or microparticle. Surface grafted CPEs are presented that use silica particles as the substrate, where a modified silane coupling agent connects the surface to the CPE by a series of covalent bonds. Two methods of preparing the surface grafted CPEs are presented. One method involves the inclusion of the surface being modified by the coupling agent and condensed with monomers that form the CPE in a grafted state to the substrate. A second method involves the formation of a CPE with terminal groups that are complimentary to functionality that has been placed on the surface of the substrate by reaction with a coupling agent. The surface grafted CPEs are also described for use as biosensors and biocides.

  一种表面接枝的共轭聚电解质（CPE）是通过将CPE与偶联基耦合到基底表面上形成的。基底可以是任何形状和大小，对于许多使用表面接枝CPE的应用来说，基底是纳米颗粒或微粒是有优势的。介绍了使用硅颗粒作为基底的表面接枝CPE，其中经过改性的硅烷偶联剂通过一系列共价键将表面连接到CPE。介绍了两种制备表面接枝CPE的方法。一种方法涉及将表面包括在偶联剂中进行修饰，并与形成接枝状态的单体缩合形成CPE。第二种方法涉及形成具有末端基团的CPE，这些基团与通过与偶联剂反应放置在基底表面上的功能互补。还描述了将表面接枝CPE用作生物传感器和生物杀菌剂的用途。
• CARBOCYANINE COMPOUNDS FOR TARGETING MITOCHONDRIA AND ERADICATING CANCER STEM CELLS
  申请人：LUNELLA BIOTECH, INC.

  公开号：US20220249438A1

  公开（公告）日：2022-08-11

  Certain carbocyanine compounds target mitochondria and may be used for eradicating cancer stem cells (CSCs). For example, MitoTracker Deep Red (MTDR) is a non-toxic, carbocyanine-based, far-red, fluorescent probe that is routinely used to chemically mark and visualize mitochondria in living cells. MTDR inhibits 3D mammosphere formation in MCF7 cells, MDA-MB-231 cells, and MDA-MB-468 cells, with an 1C-50 between 50 to 100 nM. Also, MTDR exhibited near complete inhibition of mitochondrial oxygen consumption rates and ATP production, in all three breast cancer cell lines tested, at a level of 500 nM. Nano-molar concentrations of MTDR can be used to specifically target and eradicate CSCs, by selectively interfering with mitochondrial metabolism. Other carbocyanine compounds having anti-CSC activity are described.
• US8455265B2
  申请人：——

  公开号：US8455265B2

  公开（公告）日：2013-06-04
• US8772376B2
  申请人：——

  公开号：US8772376B2

  公开（公告）日：2014-07-08
• US9465290B2
  申请人：——

  公开号：US9465290B2

  公开（公告）日：2016-10-11