| 142329-59-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 142329-59-7
• 化学式: C₂₂H₃₃NO₁₂
• 分子量: 503.504
• InChiKey: QKOCBMOOKNICBT-OEUZHLKXSA-N

反应信息

• 作为反应物：
  描述：

  、 alkaline earth salt of/the/ methylsulfuric acid 以51%的产率得到4-methoxybenzyl O-(5-acetamido-3,5-dideoxy-α-D-glycero-D-galacto-2-nonulopyranosylonic acid)-(2-3)-O-β-D-galactopyranosyl-(1-3)-2-acetamido-2-deoxy-β-D-glucopyranoside
  参考文献：
  名称：

  The use of porcine liver (2 → 3)-α-sialyltransferase in the large-scale synthesis of α-Neup5Ac-(2 → 3)-β-d-Galp-(1 → 3)-d-GlcpNAc, the epitope of the tumor-associated carbohydrate antigen CA 50

  摘要：

  Alpha-Neup5Ac-(2 --> 3)-beta-D-Galp-(1 --> 3)-D-GlcpNAc (2) and, alpha-Neup5Ac-(2 --> 3)-beta-D-Galp-(1 --> 3)-beta-D-GalpNAcOMBn were prepared on a large scale by the action of beta-D-Galp-(1 --> 3)-D-GalpNAc (2 --> 3)-alpha-sialyltransferase (partially purified from porcine liver) on beta-D-Galp-(1 --> 3)-D-GlcpNAc and beta-D-Galp-(1 --> 3)-beta-D-GlcpNAcOMBn, respectively. The trisaccharide 2 is the epitope of the tumor-associated carbohydrate antigen CA 50, highly expressed in human pancreatic adenocarcinoma.

  DOI：

  10.1016/s0008-6215(00)90555-x