3-[(1H-4-methylimidazol-1-yl)methyl]-1,2,3,4-tetrahydroquinoline | 1139879-00-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-[(1H-4-methylimidazol-1-yl)methyl]-1,2,3,4-tetrahydroquinoline
• 英文别名: 3-[(4-Methylimidazol-1-yl)methyl]-1,2,3,4-tetrahydroquinoline
• CAS: 1139879-00-7
• 化学式: C₁₄H₁₇N₃
• 分子量: 227.309
• InChiKey: SAAQXXJAZOUSNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  29.8
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Biocatalyzed synthesis of the optically pure (R) and (S) 3-methyl-1,2,3,4-tetrahydroquinoline and their use as chiral synthons for the preparation of the antithrombic (21R)- and (21S)-argatroban
  申请人：Euticals S.P.A.

  公开号：US20160122303A1

  公开（公告）日：2016-05-05

  The present invention relates to the biocatalyzed synthesis of enantiomerically pure (3R) and (3S)-methyl-1,2,3,4-tetrahydroquinoline. Said enantiomerically pure compounds are useful as chiral synthons in organic synthesis and, in particular, for the preparation of diastereomerically pure (21R) and (21S)-agratroban and its analogues. New compounds used as intermediates in the process of the invention are also disclosed.

  本发明涉及生物催化合成对映纯的(3R)和(3S)-甲基-1,2,3,4-四氢喹啉。所述对映纯化合物在有机合成中作为手性合成物起到有用作用，特别是用于制备对映异构体纯的(21R)和(21S)-阿格曲班及其类似物。本发明还公开了作为中间体在该过程中使用的新化合物。
• [EN] FARNESYL PROTEIN TRANSFERASE INHIBITORS<br/>[FR] INHIBITEURS DE LA FARNESYL PROTEINE TRANSFERASE
  申请人：SCHERING CORP

  公开号：WO2000037458A1

  公开（公告）日：2000-06-29

  Disclosed are compounds of formula (1.0), wherein R8 represents a cyclic moiety to which is bound an imodazolylalkyl group; R9 represents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.

  本发明涉及公式（1.0）的化合物，其中R8表示一个环状基团，该环状基团与一个咪唑烷基团相结合；R9表示一个氨基甲酸酯、脲、酰胺或磺酰胺基团；其余取代基的定义如本文所述。本发明还涉及使用上述化合物的治疗癌症的方法和抑制法尼酰基蛋白转移酶的方法。
• Farnesyl protein transferase inhibitors
  申请人：——

  公开号：US20030040520A1

  公开（公告）日：2003-02-27

  Disclosed are compounds of the formula: 1 wherein R 8 represents a cyclic moiety to which is bound an imodazolylalkyl group; R 9 represents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting famesyl protein transferase using the disclosed compounds.

  本发明涉及以下式子的化合物：1其中R8代表结合有一种咪唑基烷基的环状基团；R9代表氨基甲酸酯、尿素、酰胺或磺酰胺基团；其余取代基如本文中所定义。本发明还涉及使用上述化合物治疗癌症和抑制法美酰蛋白转移酶的方法。
• FARNESYL PROTEIN TRANSFERASE INHIBITORS
  申请人：SCHERING CORPORATION

  公开号：EP1140904B1

  公开（公告）日：2005-04-20
• US6362188B1
  申请人：——

  公开号：US6362188B1

  公开（公告）日：2002-03-26