7-Chlor-4-<3-octylamino-propylamino>-chinolin-1-oxid | 63680-59-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-Chlor-4-<3-octylamino-propylamino>-chinolin-1-oxid
• CAS: 63680-59-1
• 化学式: C₂₀H₃₀ClN₃O
• 分子量: 363.931
• InChiKey: VWVAUUPCKRYSIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.88
• 重原子数：
  25.0
• 可旋转键数：
  12.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  51.0
• 氢给体数：
  2.0
• 氢受体数：
  3.0

文献信息

• TREATMENTS FOR NEUROPATHY
  申请人：Children's Medical Center Corporation

  公开号：EP2240177A2

  公开（公告）日：2010-10-20
• Treatments for Neuropathy
  申请人：Corfas Gabriel

  公开号：US20110086878A1

  公开（公告）日：2011-04-14

  Small fiber neuropathy is treated or prevented by topically administering to a subject in need thereof topically active quinoline compounds or pharmaceutically acceptable salts thereof under conditions effective to treat or prevent neuropathy in the subject. Glial cell-derived neurotrophic factor (GDNF) receptors are modulated with the subject active quinoline compounds, which may be formulated in topical lotions.
• COMPOSITIONS AND METHODS FOR TREATING NEUROPATHY
  申请人：CHILDEREN'S MEDICAL CENTER CORPORATION

  公开号：US20160045487A1

  公开（公告）日：2016-02-18

  The invention features XIB4035 for the treatment of large fiber neuropathy, and combinations of XIB4035 and GDNF for the treatment of both large and small fiber neuropathies.
• US7863295B2
  申请人：——

  公开号：US7863295B2

  公开（公告）日：2011-01-04
• [EN] TREATMENTS FOR NEUROPATHY<br/>[FR] TRAITEMENTS DE LA NEUROPATHIE
  申请人：CHILDRENS MEDICAL CENTER

  公开号：WO2009102570A2

  公开（公告）日：2009-08-20

  Small fiber neuropathy is treated or prevented by topically administering to a subject in need thereof topically active quinoline compounds or pharmaceutically acceptable salts thereof under conditions effective to treat or prevent neuropathy in the subject. Glial cell- derived neurotrophic factor (GDNF) receptors are modulated with the subject active quinoline compounds, which may be formulated in topical lotions.