Tert-butyl 2-(quinolin-3-YL)acetate | 847458-92-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Tert-butyl 2-(quinolin-3-YL)acetate
• 英文别名: tert-butyl 2-quinolin-3-ylacetate
• CAS: 847458-92-8
• 化学式: C₁₅H₁₇NO₂
• 分子量: 243.3
• InChiKey: WWNJQBKZCFVUMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• NOVEL N-HYDROXY-BENZAMIDS FOR THE TREATMENT OF CANCER
  申请人：Guo Lei

  公开号：US20120065204A1

  公开（公告）日：2012-03-15

  The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt, ester or stereoisomer thereof, wherein R 1 to R 3 and X have the significances given herein. The present invention is also directed to processes for making said compounds and uses of said compounds, in particular their use as medicaments, more particularly their use as medicaments in the treatment of cancer.

  本发明提供了式（I）的化合物或其药学上可接受的盐、酯或立体异构体，其中R1至R3和X具有本文中给出的含义。本发明还涉及制备所述化合物的方法和所述化合物的用途，特别是它们作为药物的用途，更具体地说是它们作为治疗癌症的药物的用途。
• US8716285B2
  申请人：——

  公开号：US8716285B2

  公开（公告）日：2014-05-06
• [EN] AMINOPIPERIDINE AMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF<br/>[FR] DERIVES D'AMIDE D'AMINOPIPERIDINE UTILISES EN TANT QU'ANTAGONISTES D'INTEGRINE VLA-1 ET UTILISATIONS DE CEUX-CI
  申请人：ICOS CORP

  公开号：WO2005019177A1

  公开（公告）日：2005-03-03

  Compounds of formula (I) that are VLA-1 integrin antagonists are disclosed. Also disclosed are compositions containing such compounds and methods of using such compounds in treating diseases mediated, at least in part, by the VLA-1 integrin.
• [EN] NOVEL COMPOUNDS WHICH BIND TO CEREBLON, AND METHODS OF USE THEREOF<br/>[FR] NOUVEAUX COMPOSÉS QUI SE LIENT AU CÉRÉBLON ET LEURS MÉTHODES D'UTILISATION
  申请人：[en]CAPTOR THERAPEUTICS S.A.

  公开号：WO2022144416A1

  公开（公告）日：2022-07-07

  The present invention discloses novel compounds which bind to cereblon, and methods of use thereof. The compounds are represented by Formulas (I), (IIa)-(IIc), (III) and (IV), below.