(+/-)-[4-(4-chlorophenyl)-7-fluoro-5-methanesulfonyl-1-oxo-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid | 571170-80-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (+/-)-[4-(4-chlorophenyl)-7-fluoro-5-methanesulfonyl-1-oxo-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid
• 英文别名: [4-(4-chlorobenzyl)-7-fluoro-5-methanesulfonyl-1-oxo-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid；2-[4-[(4-Chlorophenyl)methyl]-7-fluoro-5-methylsulfonyl-1-oxo-2,3-dihydrocyclopenta[b]indol-3-yl]acetic acid
• CAS: 571170-80-4
• 化学式: C₂₁H₁₇ClFNO₅S
• 分子量: 449.887
• InChiKey: LXXDCYUAFJJSGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Method of Treating Pathological Blushing
  申请人：Tobert A. Jonathan

  公开号：US20070299122A1

  公开（公告）日：2007-12-27

  A method of treating pathological blushing is disclosed wherein the patient is administered a DP receptor antagonist. Compositions containing DP antagonists are also included.

  揭示了一种治疗病理性面红的方法，其中患者接受DP受体拮抗剂。还包括含有DP拮抗剂的组合物。
• Method of treating atherosclerosis, dyslipidemias and related conditions
  申请人：——

  公开号：US20040229844A1

  公开（公告）日：2004-11-18

  A method of treating atherosclerosis is disclosed wherein nicotinic acid or another nicotinic acid receptor agonist is administered to the patient in combination with a DP receptor antagonist. The DP receptor antagonist is administered to reduce, prevent or eliminate flushing that may otherwise occur.

  揭示了一种治疗动脉粥样硬化的方法，其中尼古酸或其他尼古酸受体激动剂与DP受体拮抗剂联合给患者使用。DP受体拮抗剂被用来减少、预防或消除可能发生的潮红。
• Fluoro substituted cycloalkanoindoles, compositions containing such compounds and methods of treatment
  申请人：——

  公开号：US20030158246A1

  公开（公告）日：2003-08-21

  Fluoro substituted cycloalkanoindole derivatives are antagonists of prostaglandins, and as such are useful for the treatment of prostaglandin mediated diseases.

  氟代环烷基吲哚衍生物是前列腺素拮抗剂，因此可用于治疗前列腺素介导的疾病。
• FLUORO SUBSTITUTED CYCLOALKANOINDOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
  申请人：Berthelette Carl

  公开号：US20120115921A1

  公开（公告）日：2012-05-10

  Fluoro substituted cycloalkanoindole derivatives are antagonists of prostaglandins, and as such are useful for the treatment of prostaglandin mediated diseases.

  含氟取代的环烷基吲哚衍生物是前列腺素拮抗剂，因此对于治疗前列腺素介导的疾病非常有用。
• Method of Treating Atherosclerosis, Dyslipidemias and Related Conditions
  申请人：Waters M. Gerard

  公开号：US20070244107A1

  公开（公告）日：2007-10-18

  A method of treating atherosclerosis, dyslipidemia and related conditions is disclosed wherein a compound of formula I: or a pharmaceutically acceptable salt or solvate thereof is administered to the patient in combination with a DP receptor antagonist. The DP receptor antagonist is administered to reduce, prevent or eliminate flushing that may otherwise occur.

  揭示了一种治疗动脉粥样硬化、血脂异常及相关疾病的方法，其中给患者以公式I的化合物或其药学上可接受的盐或溶剂的组合，同时与DP受体拮抗剂一起给予。DP受体拮抗剂被用于减少、预防或消除可能发生的潮红。