(2-甲氧基-5-甲基-3-吡啶基)甲醇 | 351410-48-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: (2-甲氧基-5-甲基-3-吡啶基)甲醇
• 英文名称: 5-methyl-2-methoxy-3-pyridinemethanol
• 英文别名: (2-Methoxy-5-methylpyridin-3-yl)methanol
• CAS: 351410-48-5
• 化学式: C₈H₁₁NO₂
• 分子量: 153.181
• InChiKey: WYOSXNJXIYQWEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  42.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2-甲氧基-5-甲基-3-吡啶基)甲醇 在 甲基磺酰氯 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 3-(chloromethyl)-2-methoxy-5-methylpyridine
  参考文献：
  名称：

  [EN] SMALL MOLECULE MODULATORS OF IL-17
  [FR] MODULATEURS À PETITES MOLÉCULES D'IL-17

  摘要：

  The present invention relates to a compound according to formula (I), and pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.

  公开号：

  WO2023111181A1
• 作为产物：
  描述：

  2-methoxy-5-methyl-pyridine-3-carboxylic acid 在 dimethyl sulfide borane 作用下， 以 四氢呋喃 为溶剂， 以58 %的产率得到(2-甲氧基-5-甲基-3-吡啶基)甲醇
  参考文献：
  名称：

  [EN] SMALL MOLECULE MODULATORS OF IL-17
  [FR] MODULATEURS À PETITES MOLÉCULES D'IL-17

  摘要：

  The present invention relates to a compound according to formula (I), and pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.

  公开号：

  WO2023111181A1

文献信息

• Novel piperidine compouds and drugs containing the same
  申请人：——

  公开号：US20030220368A1

  公开（公告）日：2003-11-27

  The present invention provides a novel compound having a superior Na + channel inhibition activity. Namely, it provides a compound represented by the following formula (I), a salt thereof or a hydrate of them. 1 In the formula, the ring A represents a ring represented by the formula: 2 (wherein R 1 represents a hydrogen atom etc.; and R 2 represents indicates a hydrogen atom and the like) etc.; W represents an optionally substituted C 1-6 alkylene group etc.; Z represents an optionally substituted C 6-14 aromatic hydrocarbon cyclic group etc.; and l represents an integer from 0 to 6.

  本发明提供了一种具有优越的Na + 通道抑制活性的新型化合物。即提供了由以下式（I）表示的化合物，其盐或其水合物。 在该式中，环A表示由以下式表示的环： （其中R 1 表示氢原子等；R 2 表示表示氢原子等）等；W表示可选地取代的C 1-6 烷基等；Z表示可选地取代的C 6-14 芳香烃环基等；l表示0到6的整数。
• [EN] NEW MACROCYCLIC LRRK2 KINASE INHIBITORS<br/>[FR] NOUVEAUX INHIBITEURS MACROCYCLIQUES DE LA LRRK2 KINASE
  申请人：SERVIER LAB

  公开号：WO2021224320A1

  公开（公告）日：2021-11-11

  Compounds of formula (I): wherein R, X1, X2, X3, Z1, Z2, Z3, A and Ra are as defined in the description. Medicaments.

  式(I)的化合物：其中R、X1、X2、X3、Z1、Z2、Z3、A和Ra的定义如描述中所述。药物。
• NOVEL PIPERIDINE COMPOUNDS AND DRUGS CONTAINING THE SAME
  申请人：Eisai Co., Ltd.

  公开号：EP1254904A1

  公开（公告）日：2002-11-06

  The present invention provides a novel compound having a superior Na+ channel inhibition activity. Namely, it provides a compound represented by the following formula (I), a salt thereof or a hydrate of them. In the formula, the ring A represents a ring represented by the formula: (wherein R1 represents a hydrogen atom etc.; and R2 represents indicates a hydrogen atom and the like) etc.; W represents an optionally substituted C1-6 alkylene group etc.; Z represents an optionally substituted C6-14 aromatic hydrocarbon cyclic group etc.; and l represents an integer from 0 to 6.

  本发明提供了一种具有优异 Na+ 通道抑制活性的新型化合物。即，本发明提供了由下式（I）代表的化合物、其盐或它们的水合物。 式中，环 A 代表由式表示的环： (其中 R1 表示氢原子等；R2 表示氢原子等）等；W 表示任选取代的 C1-6 亚烷基等；Z 表示任选取代的 C6-14 芳烃环基等；l 表示 0 至 6 的整数。
• ISOINDOLINONE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：EP2516417B1

  公开（公告）日：2017-10-11
• US6784192B2
  申请人：——

  公开号：US6784192B2

  公开（公告）日：2004-08-31