[Structure: see text] The total synthesis of pseudo 2-epibotcinolide (1b) through several featured synthetic approaches has been attained. First, the chiral linear precursors of the nine-membered ring compound is stereoselectively constructed by the asymmetricaldol reaction for producing beta-hydroxy ester units. Second, the key cyclization reaction to form the nine-membered lactone moiety is efficiently
We report the preparation of solid and air‐stable polyfunctionalized alkynylzinc pivalates from the corresponding alkynes using TMPZnOPiv (TMP=2,2,6,6‐tetramethylpiperidyl) as base. These organozinc pivalates are obtained as powders under mild conditions in excellent yields and can be manipulated in air for several hours without significant decomposition. These zinc reagents show an excellent reactivity
We have developed a general and highlyefficientiron(II) chloride/N-bromosuccinimide (NBS)-mediated method for the synthesis of imides and acylsulfonamides via couplings of thioesters with carboxamides/sulfonamides, and the method is simple, economical and shows practical advantages.
Investigations of the Thermal Responsiveness of 1,4,2-Oxathiazoles
作者:Russell J. Hewitt、Michelle Jui Hsien Ong、Yi Wee Lim、Brendan A. Burkett
DOI:10.1002/ejoc.201500909
日期:2015.10
The first systematic study of the thermal rearrangement/fragmentation of 5,5-disubstituted 1,4,2-oxathiazoles into isothiocyanates is reported. Structure–activity relationships reveal that the choice of substituent at the 5-position of the 1,4,2-oxathiazoles is the predominant factor to influence the ease of fragmentation.
Zinc Promoted Convenient and General Synthesis of Thiol Esters
作者:H. M. Meshram、Gondi Sudershan Reddy、K. Hima Bindu、J. S. Yadav
DOI:10.1055/s-1998-1797
日期:1998.8
Synthesis of thiolesters from acyl chlorides and thiols in the presence of activated zinc is described. The recovery of zinc and its reuse makes the procedure more economic.