[(6aR,8R,9S,9aR)-8-(2,4-dioxopyrimidin-1-yl)-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9-yl] acetate | 169886-62-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(6aR,8R,9S,9aR)-8-(2,4-dioxopyrimidin-1-yl)-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9-yl] acetate
• CAS: 169886-62-8
• 化学式: C₂₃H₄₀N₂O₈Si₂
• 分子量: 528.75
• InChiKey: DSOUYLQOMRCTLG-PSWRPDDJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.32
• 重原子数：
  35.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  118.08
• 氢给体数：
  1.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  [(6aR,8R,9S,9aR)-8-(2,4-dioxopyrimidin-1-yl)-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9-yl] acetate 在 triethylamine tris(hydrogen fluoride) 作用下， 以 乙腈 为溶剂， 反应 3.0h， 以89%的产率得到1-(2-O-acetyl-β-D-arabinofuranosyl)-uracil
  参考文献：
  名称：

  Building Blocks for Synthesis of Oligoarabinonucleotides: Preparation of Arabinonucleoside H-Phosphonates from Protected Ribonucleosides

  摘要：

  A straightforward and inexpensive synthesis of arabinonucleoside H-phosphonates has been developed. Arabinonucleosides were synthesised from protected ribonucleosides via 2'-keto derivatives. Reaction conditions have been optimised for compounds bearing labile N-protections. Further protecting group manipulation and phosphonylation gave the required H-phosphonate monomers.

  DOI：

  10.1080/15257779508010720
• 作为产物：
  描述：

  3',5'-O-(四异丙基二硅氧烷-1,3-二基)-2'-氧代尿苷 在 4-二甲氨基吡啶 、 三乙酰氧基硼氢化钠 作用下， 以 四氢呋喃 、 吡啶 、 二氯甲烷 为溶剂， 反应 20.0h， 生成 [(6aR,8R,9S,9aR)-8-(2,4-dioxopyrimidin-1-yl)-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9-yl] acetate
  参考文献：
  名称：

  Building Blocks for Synthesis of Oligoarabinonucleotides: Preparation of Arabinonucleoside H-Phosphonates from Protected Ribonucleosides

  摘要：

  A straightforward and inexpensive synthesis of arabinonucleoside H-phosphonates has been developed. Arabinonucleosides were synthesised from protected ribonucleosides via 2'-keto derivatives. Reaction conditions have been optimised for compounds bearing labile N-protections. Further protecting group manipulation and phosphonylation gave the required H-phosphonate monomers.

  DOI：

  10.1080/15257779508010720

文献信息

• Synthesis of Oligoarabinonucleotides Using H-Phosphonates
  作者：Eriks Rozners、Roger Strömberg、Erika Bizdena

  DOI：10.1080/15257779508012487

  日期：1995.5.1

  Protected arabinonucleoside H-phosphonates have been prepared starting from ribonucleosides and used in solid phase synthesis of oligoarabinonucleotides.
• [EN] COMPOSITIONS FOR EDITING MECP2 TRANSCRIPTS AND METHODS THEREOF<br/>[FR] COMPOSITIONS POUR L'ÉDITION DE TRANSCRITS MECP2 ET PROCÉDÉS ASSOCIÉS
  申请人：[en]WAVE LIFE SCIENCES LTD.

  公开号：WO2023049477A2

  公开（公告）日：2023-03-30

  Among other things, the present disclosure provides oligonucleotides, compositions and methods thereof that can bring about specific editing of a target adenosine in a target RNA molecule. Such oligonucleotides, compositions and methods are useful to treat, prevent, or ameliorate MECP2 associated disorders, diseases and syndromes that can benefit from adenosine modification.