[2-(5,6,7,8-tetrahydro-naphthalene-2-yloxy)-phenyl]-acetonitrile | 613670-95-4

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 英文名称: [2-(5,6,7,8-tetrahydro-naphthalene-2-yloxy)-phenyl]-acetonitrile
• 英文别名: 2-[2-(5,6,7,8-Tetrahydronaphthalen-2-yloxy)phenyl]acetonitrile
• CAS: 613670-95-4
• 化学式: C₁₈H₁₇NO
• 分子量: 263.339
• InChiKey: PYZOHXAGYRBFPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  33
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] 1- OR 3-THIA-BENZONAPHTHOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF<br/>[FR] 1- OU 3-THIA-BENZONAPHTHOAZULENES UTILISES COMME INHIBITEURS DE PRODUCTION DU FACTEUR DE NECROSE ET INTERMEDIAIRES DESTINES A LA PREPARATION DE CEUX-CI
  申请人：PLIVA D D

  公开号：WO2003084961A1

  公开（公告）日：2003-10-16

  The present invention relates to 1- or 3-thiabenzonaphthoazulene derivatives to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-alpha (TNF-alpha) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.

  本发明涉及1-或3-硫代苯并萘蓝类衍生物及其药学上可接受的盐和溶剂化合物，以及其制备的过程和中间体，以及其抗炎作用，特别是对肿瘤坏死因子α（TNF-alpha）产生的抑制和白细胞介素-1（IL-1）产生的抑制，以及其镇痛作用。
• 1- or 3-thia-benzonaphthoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof
  申请人：Mercep Mladen

  公开号：US20050130964A1

  公开（公告）日：2005-06-16

  The present invention relates to benzonaphthoazulene derivatives of tiophene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-α (TNF-α) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.

  本发明涉及噻吩类苯并萘蓝衍生物，其药理学上可接受的盐和溶剂，其制备过程和中间体，以及其抗炎作用，特别是抑制肿瘤坏死因子-α（TNF-α）的产生和抑制白细胞介素-1（IL-1）的产生以及其镇痛作用。
• 1-or 3-thia-benznaphthoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
  申请人：Mercep Mladen

  公开号：US20050137249A1

  公开（公告）日：2005-06-23

  The present invention relates to 1- or 3-thiabenzonaphthoazulene derivafives to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-alpha (TNF-alpha) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.

  本发明涉及1-或3-硫代苯并萘蓝衍生物及其药学上可接受的盐和溶剂化合物，涉及其制备过程和中间体，以及其抗炎作用，特别是对肿瘤坏死因子α（TNF-α）产生的抑制作用和对白细胞介素-1（IL-1）产生的抑制作用，以及其镇痛作用。
• 1- OR 3-THIA-BENZONAPHTHOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF
  申请人：PLIVA-ISTRAZIVACKI INSTITUT d.o.o.

  公开号：EP1492795A1

  公开（公告）日：2005-01-05
• US7262309B2
  申请人：——

  公开号：US7262309B2

  公开（公告）日：2007-08-28