(2Z,4E)-4-(4-methoxyphenyl)-6-oxo-2,6-diphenyl-2,4-hexadienenitrile | 1428733-71-4

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 英文名称: (2Z,4E)-4-(4-methoxyphenyl)-6-oxo-2,6-diphenyl-2,4-hexadienenitrile
• 英文别名: (2Z,4E)-4-(4-methoxyphenyl)-6-oxo-2,6-diphenylhexa-2,4-dienenitrile
• CAS: 1428733-71-4
• 化学式: C₂₅H₁₉NO₂
• 分子量: 365.431
• InChiKey: IYMKFYZZOJRVLO-JZRRLIHDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  50.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(p-tolyl)piperidine-2-carbonitrile 、 4-(4-methoxy-phenyl)-2,6-diphenyl-pyrylium; perchlorate 以 乙腈 为溶剂， 反应 0.5h， 以91%的产率得到(2Z,4E)-4-(4-methoxyphenyl)-6-oxo-2,6-diphenyl-2,4-hexadienenitrile
  参考文献：
  名称：

  An improved, safe, and efficient conversion of triarylpyrylium perchlorates to corresponding cyanodienones using Amberlite IRA 910[CN]

  摘要：

  Triarylpyrylium perchlorates are readily converted into new aromatic cyanodienones by using cyanide impregnated on anion exchange resin as a safe and efficient reagent.

  DOI：

  10.1007/s00706-012-0825-2

文献信息

• Expeditious Synthesis of Aromatic Cyanodienones Using Neutral Alumina as a Versatile Heterogeneous Catalyst
  作者：Arash Mouradzadegun、Fatemeh Abadast

  DOI：10.1080/00397911.2013.831103

  日期：2014.3.4

  Abstract The work described herein employs neutral alumina as an effective catalyst for ring opening of triarylpyrylium perchlorates to corresponding aromatic cyanodienones, which have main roles in biological activities. The present porous catalyst has several advantages, it is inexpensive, thermally and mechanically stable, nontoxic, and highly resistant against organic solvents. It increases the

  摘要 本文描述的工作采用中性氧化铝作为高氯酸三芳基吡喃开环生成相应的芳族氰二烯酮的有效催化剂，后者在生物活性中起主要作用。本多孔催化剂具有几个优点，它价格便宜、热和机械稳定、无毒且对有机溶剂具有高度耐受性。与常规反应条件相比，它可将反应速率提高许多倍。此外，回收的氧化铝可以多次使用而不会严重降低活性。[本文提供补充材料。访问出版商的 Synthetic Communications® 在线版，获取以下免费补充资源：完整的实验和光谱细节。] 图形摘要
• An Innovative and Atom-Efficient Synthesis of Bioactive 2-Aroylfuran Derivatives Using Macroporous Polymer-Supported Cyanide
  作者：Arash Mouradzadegun、Fatemeh Abadast

  DOI：10.1055/s-0033-1340301

  日期：——

  A novel and safe approach was developed for the synthesis of bioactive 2-aroyl-3,5-diarylfurans in excellent yields by using a cyanide-impregnated anion-exchange resin as a versatile reagent. The possibility of reusing the polymer-supported reagent makes the process environmentally friendly and economically advantageous.