匹立溴铵 | 14222-46-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 匹立溴铵
• 英文名称: Phenanthridinium, 3-amino-8-((2-amino-1,6-dimethylpyridinium-4-yl)amino)-6-(p-aminophenyl)-5-methyl-, dibromide
• 英文别名: 8-[(2-amino-1,6-dimethylpyrimidin-4-ylidene)amino]-6-(4-aminophenyl)-5-methylphenanthridin-5-ium-3-amine;bromide;hydrobromide
• CAS: 14222-46-9
• 化学式: C26H27Br2N7
• 分子量: 597.3
• InChiKey: IXNYZBNLCCQASS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.49
• 重原子数：
  35
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  111
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• Liposomes, process for their preparation and compositions containing them
  申请人：Fluck, David John

  公开号：EP0193414A2

  公开（公告）日：1986-09-03

  The invention relates to liposomes which comprise a phospholipid and a trypanocidally active phenanthridine or diamidine compound or quinapyramine, processes for their preparation and pharmaceutical compositions containing them.

  本发明涉及由磷脂和具有锥虫活性的菲啶或二脒化合物或喹氨嘧啶组成的脂质体、其制备工艺以及含有这些脂质体的药物组合物。
• Chemical derivatives and use thereof as antitelomerase agents
  申请人：——

  公开号：US20020103169A1

  公开（公告）日：2002-08-01

  Novel anticancer agents of the phenanthridine class having a specific mechanism of action and cancer therapy methods are described, including the novel chemical compounds and their therapeutic use thereof in humans.

  介绍了具有特定作用机理的菲啶类新型抗癌剂和癌症治疗方法，包括新型化合物及其在人体中的治疗用途。
• Compositions for the treatment of chronic trypanosomiasis infections
  申请人：Merck & Co., Inc.

  公开号：EP0006752B1

  公开（公告）日：1982-12-22
• Methods and devices for the treatment of ocular conditions
  申请人：deJuan Eugene

  公开号：US20060110428A1

  公开（公告）日：2006-05-25

  Featured is a method for instilling one or more bioactive agents into ocular tissue within an eye of a patient for the treatment of an ocular condition, the method comprising concurrently using at least two of the following bioactive agent delivery methods (A)-(C): (A) implanting a sustained release delivery device comprising one or more bioactive agents in a posterior region of the eye so that it delivers the one or more bioactive agents into the vitreous humor of the eye; (B) instilling (e.g., injecting or implanting) one or more bioactive agents subretinally; and (C) instilling (e.g., injecting or delivering by ocular iontophoresis) one or more bioactive agents into the vitreous humor of the eye.