(R) (-)-2-(4-isobutylphenyl)-4-phenylbutan-3-one | 709040-19-7

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 英文名称: (R) (-)-2-(4-isobutylphenyl)-4-phenylbutan-3-one
• 英文别名: (3R)-3-[4-(2-methylpropyl)phenyl]-1-phenylbutan-2-one
• CAS: 709040-19-7
• 化学式: C₂₀H₂₄O
• 分子量: 280.41
• InChiKey: OIGZBRIFCOWGTP-MRXNPFEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] CHIRAL ARYLKETONES IN THE TREATEMENT OF NEUTROPHIL-DEPENDENT INFLAMMATORY DESEASES<br/>[FR] ARYLCETONES CHIRALES UTILISEES POUR TRAITER DES MALADIES INFLAMMATOIRES DEPENDANT DES NEUTROPHILES
  申请人：DOMPE SPA

  公开号：WO2004052830A1

  公开（公告）日：2004-06-24

  ABSTRACT The compounds of formula (I): where Ar is an aromatic ring and Ra, Rb, are as defined in the description, are useful in therapy as drugs for the treatment of diseases mediated by infiltrations of neutrophils induced by IL-8, such as psoriasis, rheumatoid arthritis, ulcerative cholitis and for the treatment of damages caused by ischemia and reperfusion.

  摘要 公式(I)的化合物：其中Ar是芳香环，Ra，Rb如描述中所定义，可用作治疗药物，用于治疗由IL-8诱导的中性粒细胞浸润介导的疾病，如牛皮癣、类风湿关节炎、溃疡性结肠炎以及用于治疗缺血再灌注引起的损伤。
• Chiral arylketones in the treatment of neutrophil-dependent inflammatory diseases
  申请人：Allegretti Marcello

  公开号：US20060247297A1

  公开（公告）日：2006-11-02

  The compounds of formula (I): where Ar is an aromatic ring and Ra, Rb, are as defined in the description, are useful in therapy as drugs for the treatment of diseases mediated by infiltrations of neutrophils induced by IL-8, such as psoriasis, rheumatoid arthritis, ulcerative cholitis and for the treatment of damages caused by ischemia and reperfusion.

  化合物的公式（I）：其中Ar是芳香环，Ra，Rb如描述中定义的那样，可用作治疗剂，用于治疗由IL-8诱导的中性粒细胞浸润介导的疾病，如牛皮癣，类风湿性关节炎，溃疡性结肠炎，并用于治疗缺血再灌注所致的损伤。
• CHIRAL ARYLKETONES IN THE TREATMENT OF NEUTROPHIL-DEPENDENT INFLAMMATORY DISEASES
  申请人：ALLEGRETTI Marcello

  公开号：US20090203652A1

  公开（公告）日：2009-08-13

  The compounds of formula (I): where Ar is an aromatic ring and Ra, Rb, are as defined in the description, are useful in therapy as drugs for the treatment of diseases mediated by infiltrations of neutrophils induced by IL-8, such as psoriasis, rheumatoid arthritis, ulcerative cholitis and for the treatment of damages caused by ischemia and reperfusion.

  公式（I）的化合物：其中Ar是芳香环，Ra，Rb如描述中所定义，可用于治疗由IL-8介导的中性粒子浸润引起的疾病，如牛皮癣，类风湿性关节炎，溃疡性结肠炎以及治疗缺血再灌注所致的损伤，作为药物在疗法上是有用的。
• CHIRAL ARYLKETONES IN THE TREATEMENT OF NEUTROPHIL-DEPENDENT INFLAMMATORY DESEASES
  申请人：Dompé S.P.A.

  公开号：EP1581474A1

  公开（公告）日：2005-10-05
• US9328057B2
  申请人：——

  公开号：US9328057B2

  公开（公告）日：2016-05-03