4-(4-iodobenzoyl)-3-methyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-one | 1616511-94-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(4-iodobenzoyl)-3-methyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-one
• CAS: 1616511-94-4
• 化学式: C₁₄H₁₂IN₃O₂
• 分子量: 381.173
• InChiKey: JBIUTLYUMIBGJC-UHFFFAOYSA-N

物化性质

• 熔点：
  328-330 °C
• 沸点：
  505.1±60.0 °C(predicted)
• 密度：
  1.92±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  丙二酸环(亚)异丙酯 、 3-氨基-5-甲基吡唑 、 2,2-dihydroxy-1-(4-iodo-phenyl)-ethanone 以 乙醇 为溶剂， 以68%的产率得到4-(4-iodobenzoyl)-3-methyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-one
  参考文献：
  名称：

  Three-Component Synthesis of 4-Aroyl-2(1),4,5,7-Tetrahydropyrazolo[3,4-b]Pyridin-6-Ones and Their Properties

  摘要：

  Inspired by the concept of multicomponent reactions, a novel one-pot synthesis involving arylglyoxals, 5-aminopyrazoles, and Meldrum's acid has been developed and employed for the creation of a small library of 4-aroyl-2(1),4,5,7-tetrahydropyrazolo[3,4-b]pyridin-6-ones. The alkylation, acylation, reduction, and oxidation reactions of 4-aroyl-3-methyl-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridin-6-ones have been studied.

  DOI：

  10.1007/s10593-014-1502-7