neosedumoside IV | 1160937-75-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: neosedumoside IV
• 英文别名: (3R,3aS,7aR)-3-hydroxy-3a,7,7-trimethyl-3-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-2,4,6,7a-tetrahydro-1H-inden-5-one
• CAS: 1160937-75-6
• 化学式: C₁₉H₃₂O₈
• 分子量: 388.458
• InChiKey: JFEGTHMFRZRUKQ-UICYTCRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  137
• 氢给体数：
  5
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  neosedumoside IV 在 水 、 almond β-glucosidase 作用下， 反应 16.0h， 以93%的产率得到neosarmentol IV
  参考文献：
  名称：

  Novel megastigmanes with lipid accumulation inhibitory and lipid metabolism-promoting activities in HepG2 cells from Sedum sarmentosum

  摘要：

  Four novel megastigmanes, neosedumosides I (1), II (2), III(3), and IV (4) were isolated from the whole plant of Sedum sarmentosum (Crassulaceae). Absolute stereostructures of these constituents were determined on the basis of chemical and physicochemical evidence. Among them, 1-3 were found to show lipid accumulation inhibitory activity in HepG2 cells. Furthermore, 2 and 3 were found to also show lipid metabolism-promoting activity. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.03.040