(-)-(5S)-4-(4,4-difluorocyclohexyl)-3-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-2-{1-[5-(4-hydroxypiperidin-1-yl)pyrimidin-2-yl]piperidin-4-yl}-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol | 1354494-93-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (-)-(5S)-4-(4,4-difluorocyclohexyl)-3-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-2-{1-[5-(4-hydroxypiperidin-1-yl)pyrimidin-2-yl]piperidin-4-yl}-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol
• 英文别名: (5S)-4-(4,4-difluorocyclohexyl)-3-[(S)-fluoro-[4-(trifluoromethyl)phenyl]methyl]-2-[1-[5-(4-hydroxypiperidin-1-yl)pyrimidin-2-yl]piperidin-4-yl]-7,7-dimethyl-6,8-dihydro-5H-quinolin-5-ol
• CAS: 1354494-93-1
• 化学式: C₃₉H₄₇F₆N₅O₂
• 分子量: 731.825
• InChiKey: ANOPNZMZDISQDN-NHZFLZHXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  52
• 可旋转键数：
  6
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  85.6
• 氢给体数：
  2
• 氢受体数：
  13

文献信息

• Substituted Pyridine Compound
  申请人：Nakamura Tsuyoshi

  公开号：US20130109653A1

  公开（公告）日：2013-05-02

  The present invention provides a substituted pyridine compound or a pharmacologically acceptable salt thereof which has excellent CETP inhibition activity and is useful as a medicament. The present invention provides a compound represented by a general formula (I), wherein R 1 is H, optionally substituted alkyl, OH, optionally substituted alkoxy, alkylsulfonyl, optionally substituted amino, carboxy, optionally substituted carbonyl, CN, halogeno, optionally substituted phenyl, optionally substituted aromatic heterocyclyl, optionally substituted saturated heterocyclyl, optionally substituted saturated heterocyclyloxy or optionally substituted saturated heterocyclylcarbonyl, etc., and the like.

  本发明提供了一种取代吡啶化合物或其药理学上可接受的盐，具有优异的CETP抑制活性，并可用作药物。本发明提供了一种由通式（I）表示的化合物，其中R1为H，可选地取代的烷基，OH，可选地取代的烷氧基，烷基磺酰基，可选地取代的氨基，羧基，可选地取代的羰基，CN，卤素，可选地取代的苯基，可选地取代的芳香杂环基，可选地取代的饱和杂环基，可选地取代的饱和杂环氧基或可选地取代的饱和杂环羰基等。
• Substituted PyridineCompound
  申请人：Nakamura Tsuyoshi

  公开号：US20140005143A2

  公开（公告）日：2014-01-02

  The present invention provides a substituted pyridine compound or a pharmacologically acceptable salt thereof which has excellent CETP inhibition activity and is useful as a medicament. The present invention provides a compound represented by a general formula (I), wherein R 1 is H, optionally substituted alkyl, OH, optionally substituted alkoxy, alkylsulfonyl, optionally substituted amino, carboxy, optionally substituted carbonyl, CN, halogeno, optionally substituted phenyl, optionally substituted aromatic heterocyclyl, optionally substituted saturated heterocyclyl, optionally substituted saturated heterocyclyloxy or optionally substituted saturated heterocyclylcarbonyl, etc., and the like.

  本发明提供了一种替代吡啶化合物或其药学上可接受的盐，具有优异的CETP抑制活性，并可用作药物。本发明提供了一种由通式（I）表示的化合物，其中R1为H、可选取代烷基、OH、可选取代烷氧基、烷基磺酰基、可选取代氨基、羧基、可选取代羰基、CN、卤素、可选取代苯基、可选取代芳香杂环基、可选取代饱和杂环基、可选取代饱和杂环氧基或可选取代饱和杂环羰基等。
• SUBSTITUTED PYRIDINE COMPOUND
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2592076B1

  公开（公告）日：2015-05-13
• Cosmetic Composition Containing Oligopeptides
  申请人：Bardey Vincent

  公开号：US20130108562A1

  公开（公告）日：2013-05-02

  The invention is directed to the cosmetic use of tetrapeptides according to formula (I) R 1 -Val-Leu-Leu-Lys-R 2 (I) wherein R 1 is linked to the NH2-terminal group of the peptide and is chosen from the group consisting of —H, a linear saturated or unsaturated or branched saturated or unsaturated acyl group having 1 to 24 carbon atoms, which may be functionalized by a —OH, —SH, —COOH or —CONH 2 group wherein R 2 is the terminal carboxylic group of the peptide either as —COOR 3 or —CO—NH 2 , and wherein R 3 is chosen from the group consisting of —H, a linear saturated or unsaturated or branched saturated or unsaturated alkyl group having 1 to 24 carbon atoms, which may be functionalized by a —OH, —SH, —COOH or —CONH 2 group. The invention is also directed to the respective tetrapeptides and cosmetic compositions containing these.
• SYNERGISTIC TETRAPEPTIDE COMBINATION
  申请人：BASF Corporation

  公开号：US20190336429A1

  公开（公告）日：2019-11-07

  The present invention discloses a cosmetic composition for the treatment of forehead wrinkles, nose fold, crow's feet, cheek density, and cheek hypoechogenic dermal factor.