1-[4-[(2S)-3-Hydroxy-2-[((2S)-2-hydroxy-3-phenoxypropyl)amino]propyl]phenyl]ethanone | 357408-89-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[4-[(2S)-3-Hydroxy-2-[((2S)-2-hydroxy-3-phenoxypropyl)amino]propyl]phenyl]ethanone
• 英文别名: 1-[4-[(2S)-3-hydroxy-2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]propyl]phenyl]ethanone
• CAS: 357408-89-0
• 化学式: C₂₀H₂₅NO₄
• 分子量: 343.423
• InChiKey: HDQCVTPZTQAGTQ-OALUTQOASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  25
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  78.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Aminoalcohol derivatives
  申请人：——

  公开号：US20030073846A1

  公开（公告）日：2003-04-17

  A compound of the formula (I) wherein X 1 ? is bond or —O(CH 2 ) m — (in which m is an integral number of 1, 2 or 3); X 2 is bond, —(CH 2 ) n —, etc. (in which n is an integral number of 1, 2 or 3); R 1 is hydrogen or amino protective group; R 2 is hydroxy(lower)alkyl or (lower)alkoxy(lower)alkyl; A is phenyl, pyridyl, indolyl or carbazolyl, each of which may be substituted with one or two substituent(s) selected from the group consisting of halogen, hydroxy, lower alkyl, etc.; and B is phenyl or pyridyl, each of which may be substituted with one or two substituent(s) selected from the group consisting of halogen, hydroxy, nitro, etc.; and a pharmaceutically acceptable salt thereof which is useful as a medicament. 1

  化合物的化学式(I)中，其中X1是键或—O(CH2)m—（其中m是1、2或3的整数）；X2是键，—( )n—等（其中n是1、2或3的整数）；R1是氢或氨基保护基；R2是羟基(较低)烷基或(较低)烷氧(较低)烷基；A是苯基、吡啶基、吲哚基或咔唑基，每种基可能被取代为一个或两个来自卤素、羟基、较低烷基等的取代基；B是苯基或吡啶基，每种基可能被取代为一个或两个来自卤素、羟基、硝基等的取代基；以及其药学上可接受的盐，可用作药物。
• AMINOALCOHOL DERIVATIVES
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP1292564A2

  公开（公告）日：2003-03-19
• [EN] AMINOALCOHOL DERIVATIVES<br/>[FR] DERIVE D'AMINOALCOOL
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2001062705A2

  公开（公告）日：2001-08-30

  A compound of the formula (I) wherein X1 is bond or -O(CH2)m- (in which m is an integral number of 1, 2 or 3); X2 is bond, -(CH2)n-, etc. (in which n is an integral number of 1, 2 or 3); R1 is hydrogen or amino protective group; R2 is hydroxy(lower)alkyl or (lower)alkoxy(lower)alkyl; A is phenyl, pyridyl, indolyl or carbazolyl, each of which may be substituted with one or two substituent(s) selected from the group consisting of halogen, hydroxy, lower alkyl, etc.; and B is phenyl or pyridyl, each of which may be substituted with one or two substituent(s) selected from the group consisting of halogen, hydroxy, nitro, etc.; and a pharmaceutically acceptable salt thereof which is useful as a medicament.