二盐酸法舒地尔 | 203911-27-7

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 中文名称: 二盐酸法舒地尔
• 中文别名: 盐酸法舒地尔
• 英文名称: 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline dihydrochloride
• 英文别名: 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline;dihydrochloride
• CAS: 203911-27-7
• 化学式: C14H19Cl2N3O2S
• 分子量: 364.3
• InChiKey: NOXXIYDYFSNHDF-UHFFFAOYSA-N

物化性质

• 密度：
  1.289
• 闪点：
  260℃
• 溶解度：
  H2O：>10mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  2.06
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  70.7
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 海关编码：
  2942000000

文献信息

• THERAPEUTIC AGENT FOR OCULAR FUNDUS DISEASE
  申请人：KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION

  公开号：US20140378441A1

  公开（公告）日：2014-12-25

  Disclosed herein is a prophylactic or therapeutic agent for ocular fundus disease, especially diabetic retinopathy or age-related macular degeneration. The prophylactic or therapeutic agent for ocular fundus disease comprising: (S)-(−)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine, a salt thereof, or a solvate thereof, as an active ingredient.

  本文揭示了一种用于眼底疾病的预防或治疗剂，特别是糖尿病视网膜病变或年龄相关性黄斑变性。该眼底疾病的预防或治疗剂包括：(S)-(−)-1-(4-氟-5-异喹啉磺酰基)-2-甲基-1,4-同环哌嗪，其盐或溶剂化合物，作为活性成分。
• REMEDY FOR GLAUCOMA COMPRISING Rho KINASE INHIBITOR AND PROSTAGLANDINS
  申请人：SANTEN PHARMACEUTICAL CO., LTD.

  公开号：EP1541151A1

  公开（公告）日：2005-06-15

  A subject of the present invention is to find utility of a combination of a Rho kinase inhibitor and prostaglandins as a therapeutic agent for glaucoma. Actions of reducing intraocular pressure are complemented and/or enhanced each other by combining the Rho kinase inhibitor with prostaglandins. For the administration mode, each drug can be administered in combination or in mixture.

  本发明的一个主题是发现 Rho 激酶抑制剂和前列腺素的组合作为青光眼治疗剂的效用。通过将 Rho 激酶抑制剂与前列腺素结合使用，可相互补充和/或增强降低眼内压的作用。在给药方式上，每种药物可以联合给药，也可以混合给药。
• Use of 1-(5-isoquinolinesulfonyl) homopiperazine for treating and preventing hypopigmentary disorders
  申请人：Switch Biotech Aktiengesellschaft

  公开号：EP1550446A1

  公开（公告）日：2005-07-06

  The invention relates to the use of 1-(5-isoquinolinesulfonyl)homopiperazine, its isomers and salts for treating and/or preventing hypopigmentary disorders.

  本发明涉及 1-(5-异喹啉磺酰基)均哌嗪、其异构体和盐在治疗和/或预防色素减退症方面的用途。
• Therapeutic agent for glaucoma comprising rho kinase inhibitor and prostaglandin
  申请人：Santen Pharmaceutical Co., Ltd

  公开号：EP2314299A1

  公开（公告）日：2011-04-27

  A subject of the present invention is to find utility of a combination of a Rho kinase inhibitor and prostaglandins as a therapeutic agent for glaucoma. Actions of reducing intraocular pressure are complemented and/or enhanced each other by combining the Rho kinase inhibitor with prostaglandins. For the administration mode, each drug can be administered in combination or in mixture.

  本发明的一个主题是发现 Rho 激酶抑制剂和前列腺素的组合作为青光眼治疗剂的效用。通过将 Rho 激酶抑制剂与前列腺素结合使用，可相互补充和/或增强降低眼内压的作用。在给药方式上，每种药物可以联合给药，也可以混合给药。
• METHOD OF PRODUCING PANCREATIC HORMONE-PRODUCING CELLS
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP2604685A1

  公开（公告）日：2013-06-19

  The present invention aims to provide a production method of pancreatic hormone-producing cells in a form more mimicking the pancreatogenesis. A method of producing pancreatic hormone-producing cells, comprising subjecting stem cells to the following steps (1) - (6) : (1) a step of cultivating stem cells in a medium containing a Rho kinase inhibitor (2) a step of cultivating the cells obtained in the aforementioned step (1) in a medium containing a GSK3 inhibitor (3) a step of cultivating the cells obtained in the aforementioned step (2) in a medium containing GSK3 inhibitor and an activator of activin receptor-like kinase-4,7 (4) a step of forming a cell mass from the cells obtained in the aforementioned (3), and cultivating the cell mass in a suspension state in a medium (5) a step of cultivating the cells obtained in the aforementioned step (4) in a medium containing a retinoic acid receptor agonist, an inhibitor of AMP-activated protein kinase and/or activin receptor-like kinase-2,3,6, an inhibitor of activin receptor-like kinase-4,5,7 and a cell growth factor (6) a step of cultivating the cells obtained in the aforementioned step (5).

  本发明旨在提供一种生产胰腺激素分泌细胞的方法，其形式更模拟胰腺的生成。 一种生产胰腺激素产生细胞的方法，包括使干细胞经受以下步骤(1)-(6)： (1) 在含有 Rho 激酶抑制剂的培养基中培养干细胞的步骤 (2) 在含有 GSK3 抑制剂的培养基中培养上述步骤(1)中获得的细胞的步骤 (3) 在含有 GSK3 抑制剂和活化素受体样激酶激活剂-4,7 的培养基中培养上述步骤（2）中获得的细胞的步骤 (4) 将上述步骤(3)中获得的细胞形成细胞团，并在培养基中以悬浮状态培养该细胞团的步骤 (5) 在含有维甲酸受体激动剂、AMP 活化蛋白激酶和/或活化因子受体样激酶-2,3,6 的抑制剂、活化因子受体样激酶-4,5,7 的抑制剂和细胞生长因子的培养基中培养上述步骤（4）中获得的细胞的步骤 (6) 培养上述步骤（5）中获得的细胞。