7-Hydroxy-6-methoxy-4-methyl-chinolin | 15463-14-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-Hydroxy-6-methoxy-4-methyl-chinolin
• 英文别名: 6-methoxy-4-methyl-quinolin-7-ol；6-Methoxy-4-methylquinolin-7-ol
• CAS: 15463-14-6
• 化学式: C₁₁H₁₁NO₂
• 分子量: 189.214
• InChiKey: QITNGHXYPOYFRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  42.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PROCESS FOR THE PREPARATION OF 6-(7-((1-AMINOCYCLOPROPYL)METHOXY)-6-METHOXYQUINOLIN-4-YLOXY)-N-METHYL-1-NAPHTHAMIDE AND SYNTHETIC INTERMEDIATES THEREOF
  申请人：Spinelli Silvano

  公开号：US20120010415A1

  公开（公告）日：2012-01-12

  A process for the preparation in high yields and purity of the compound 6-(7-4(1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide of formula (I) and of the pharmaceutically acceptable salts thereof is described. The process has various advantages over those previously described, in particular it avoids the use of acyl azide intermediates and their Curtius rearrangement. Novel intermediates useful for the preparation of compound (I) are also described.

  本发明描述了一种制备化合物6-(7-4(1-氨基环丙基)甲氧基)-6-甲氧基喹啉-4-氧基)-N-甲基-1-萘酰胺（I）及其药学上可接受的盐的高产率和高纯度的方法。该方法相对于以前描述的方法具有各种优点，特别是避免了使用酰基叠氮中间体及其Curtius重排反应。还描述了用于制备化合物（I）的新型中间体。
• Process for the Preparation of 6-(7-((1-Aminocyclopropyl)Methoxy)-6-Methoxyquinolin-4-Yloxy)-N-Methyl-1-Naphthamide and Synthetic Intermediates Thereof
  申请人：Clovis Oncology Italy S.r.l.

  公开号：US20150191429A1

  公开（公告）日：2015-07-09

  A process for the preparation in high yields and purity of the compound 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide of formula (I) and of the pharmaceutically acceptable salts thereof is described. The process has various advantages over those previously described, in particular it avoids the use of acyl azide intermediates and their Curtius rearrangement. Novel intermediates useful for the preparation of compound (I) are also described.

  本发明提供了一种制备式(I)化合物及其药学上可接受的盐的高产率和高纯度的方法。该方法与先前描述的方法相比具有各种优点，特别是它避免了使用酰基叠氮中间体及其Curtius重排。还描述了用于制备化合物(I)的新型中间体。
• QUINOLINYL-SUBSTITUTED CARBOXYLIC ACID COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF
  申请人：Beijing Konruns Pharmaceutical Co., Ltd.

  公开号：EP3530654A1

  公开（公告）日：2019-08-28

  The present application provides a quinolyl-substituted carboxylic acid compound as shown in formula (I) or a pharmaceutically acceptable salt thereof, as well as a method for preparing the compound, a use of the compound, and a formulation containing the quinolyl-substituted carboxylic acid compound or the pharmaceutically acceptable salt thereof. This type of compounds are inhibitors for AXL and/or VEGFR2 protein kinase, and can be used to treat diseases caused by abnormality of the two protein kinases, such as, tumor, etc.;

  本申请提供了一种如式（I）所示的喹啉基取代的羧酸化合物或其药学上可接受的盐，以及该化合物的制备方法、该化合物的用途和含有该喹啉基取代的羧酸化合物或其药学上可接受的盐的制剂。这类化合物是 AXL 和/或 VEGFR2 蛋白激酶的抑制剂，可用于治疗由这两种蛋白激酶异常引起的疾病，如肿瘤等；
• Process for the preparation of 4-phenoxy quinoline derivatives
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP1777218B1

  公开（公告）日：2008-12-31
• US8642767B2
  申请人：——

  公开号：US8642767B2

  公开（公告）日：2014-02-04