methyl 4-((3-(methoxycarbonyl)-5-hydroxy-1-phenyl-1H-pyrazol-4-yl)(4-nitrophenyl)methyl)-5-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate | 1380413-94-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: methyl 4-((3-(methoxycarbonyl)-5-hydroxy-1-phenyl-1H-pyrazol-4-yl)(4-nitrophenyl)methyl)-5-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate
• CAS: 1380413-94-4
• 化学式: C₂₉H₂₃N₅O₈
• 分子量: 569.53
• InChiKey: NXNUMBWDYPDDON-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  对硝基苯甲醛 、 苯肼 、 丁炔二酸二甲酯 在 cerium(IV) oxide 作用下， 以 水 为溶剂， 反应 0.38h， 以90%的产率得到methyl 4-((3-(methoxycarbonyl)-5-hydroxy-1-phenyl-1H-pyrazol-4-yl)(4-nitrophenyl)methyl)-5-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate
  参考文献：
  名称：

  使用CeO 2纳米颗粒作为高效绿色催化剂，多组分合成C系双吡唑-5-醇

  摘要：

  摘要 CeO 2纳米颗粒已被用作在70°C的水中通过苯肼，乙炔二羧酸酯和芳族醛的假五组分反应制备C系双吡唑-5-醇的有效催化剂。该协议的一些重要特征是不使用危险的有机溶剂，而且原子经济，反应时间短，催化剂负载少，产品收率高。 图形概要

  DOI：

  10.1007/s11164-015-2057-7

文献信息

• Synthesis of 4,4′-(arylmethylene)bis(3-carboxymethyl-1-phenyl-1<i>H</i>-pyrazol-5-ol)s using ionic liquid attached to colloidal silica nanoparticles in water
  作者：Hossein Shahbazi-Alavi、Javad Safaei-Ghomi、Samane Esmaili、Seyed Hadi Nazemzadeh

  DOI：10.3184/174751917x15000317104529

  日期：2017.8

  An efficient synthesis of 10 4,4′-(arylmethylene)bis(3-carboxymethyl-1-phenyl-1H-pyrazol-5-ol)s, eight of which are novel, was achieved by a one-pot three-component reaction of phenylhydrazine, dimethyl acetylenedicarboxylate and an arylaldehyde using bis(1(3-methoxysilylpropyl)-3-methyl-imidazolium) copper tetrachloride tethered to colloidal silica nanoparticles as catalyst under microwave irradiation

  通过一锅三组分反应实现了 10 4,4'-（芳基亚甲基）双（3-羧甲基-1-苯基-1H-吡唑-5-醇）的有效合成，其中八种是新型的苯肼、乙炔二甲酸二甲酯和芳醛使用双（1（3-甲氧基甲硅烷基丙基）-3-甲基-咪唑鎓）四氯化铜连接到胶体二氧化硅纳米粒子作为催化剂，在水中微波辐射下。本方法的优点是原子经济、催化活性高、产率高、反应时间短和利用微波加热作为清洁程序。催化剂是可回收的。
• CeO₂/CuO@GQDs@NH₂ Nanocomposite as a Reusable Catalyst for the Preparation of <i>bis-</i>Pyrazoles
  作者：Mohammad Sadegh Dehghan-Manshadi、Ali Kareem Abbas、Mozhgan Esfandiari、Hossein Shahbazi-Alavi、Javad Safaei-Ghomi

  DOI：10.1080/00304948.2021.1873675

  日期：2021.5.4
• Multicomponent domino reactions of acetylenedicarboxylates: divergent synthesis of multi-functionalized pyrazolones and C-tethered bispyrazol-5-ols
  作者：Xing-Chao Tu、Hui Feng、Man-Su Tu、Bo Jiang、Shu-Liang Wang、Shu-Jiang Tu

  DOI：10.1016/j.tetlet.2012.04.051

  日期：2012.6

  An efficient and practical methodology of selectively divergent synthesis of arylidene pyrazolones and C-tethered bispyrazol-5-ols via multicomponent domino reactions of acetylenedicarboxylates, phenylhydrazine and aromatic aldehydes has been developed. The electron-donating aryl groups (EDAG)-attached aldehydes resulted in the pyrazolone skeleton, whereas the electron-withdrawing aryl groups (EWAG) led to the C-tethered bispyrazol-5-ols with simultaneous formation of two new pyrazole rings. (C) 2012 Elsevier Ltd. All rights reserved.