(3R)-N-methyl-N-[1-(6-nitro-2-quinolinyl)-3-pyrrolidinyl]propanamide | 801252-92-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (3R)-N-methyl-N-[1-(6-nitro-2-quinolinyl)-3-pyrrolidinyl]propanamide
• 英文别名: N-methyl-N-[(3R)-1-(6-nitroquinolin-2-yl)pyrrolidin-3-yl]propanamide
• CAS: 801252-92-6
• 化学式: C₁₇H₂₀N₄O₃
• 分子量: 328.371
• InChiKey: XGVLYSMGINCNLJ-CQSZACIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  82.3
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• 2-Aminoquinoline derivatives
  申请人：Moriya Minoru

  公开号：US20060287340A1

  公开（公告）日：2006-12-21

  This invention provides 2-aminoquinoline derivatives represented by a general formula [I] [in which R 1 and R 2 either stand for lower alkyl, lower cycloalkyl, etc., or R 1 and R 2 together form an aliphatic nitrogen-containing heterocycle with the nitrogen atom to which they bind; R 3 , R 4 , R 5 , R 6 and R 7 stand for hydrogen, lower alkyl, etc.; R 8 stands for lower alkyl, lower alkyloxy, etc.; and n stands for an integer of 0-4]. The compounds act as melanin concentrating hormone receptor antagonist, and are useful as medicines for central nervous system disorders, cardiovascular disorders and metabolic disorders.

  本发明提供了由通式[I]表示的2-氨基喹啉衍生物[其中R1和R2代表低碳基、低环烷基等，或者R1和R2共同形成一个与它们结合的氮杂环的脂肪族氮杂环；R3、R4、R5、R6和R7代表氢、低碳基等；R8代表低碳基、低碳基氧杂基等；n代表0-4的整数]。这些化合物作为黑色素浓集激素受体拮抗剂，并且可用于治疗中枢神经系统疾病、心血管疾病和代谢性疾病。
• 2-AMINOQUINOLINE DERIVATIVE
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP1630162A1

  公开（公告）日：2006-03-01

  This invention provides 2-aminoquinoline derivatives represented by a general formula [I] [in which R1 and R2 either stand for lower alkyl, lower cycloalkyl, etc., or R1 and R2 together form an aliphatic nitrogen-containing heterocycle with the nitrogen atom to which they bind; R3, R4, R5, R6 and R7 stand for hydrogen, lower alkyl, etc.; R8 stands for lower alkyl, lower alkyloxy, etc.; and n stands for an integer of 0 - 4]. The compounds act as melanin concentrating hormone receptor antagonist, and are useful as medicines for central nervous system disorders, cardiovascular disorders and metabolic disorders.

  本发明提供由通式 [I] 表示的 2-氨基喹啉衍生物 [其中R1和R2代表低级烷基、低级环烷基等，或者R1和R2与它们结合的氮原子一起形成脂肪族含氮杂环；R3、R4、R5、R6和R7代表氢、低级烷基等；R8代表低级烷基、低级烷氧基等；n代表0-4的整数]。这些化合物具有黑色素浓缩激素受体拮抗剂的作用，可作为治疗中枢神经系统疾病、心血管疾病和代谢紊乱的药物。
• US7485647B2
  申请人：——

  公开号：US7485647B2

  公开（公告）日：2009-02-03