triethyl-(3,3,7-trimethyl-4-triethylsilyloxytrideca-7,12-dienoxy)silane | 1114553-22-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: triethyl-(3,3,7-trimethyl-4-triethylsilyloxytrideca-7,12-dienoxy)silane
• CAS: 1114553-22-8
• 化学式: C₂₈H₅₈O₂Si₂
• 分子量: 482.938
• InChiKey: NUIOLCSJKXWLKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.9
• 重原子数：
  32
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  triethyl-(3,3,7-trimethyl-4-triethylsilyloxytrideca-7,12-dienoxy)silane 在 草酰氯 、 二甲基亚砜 作用下， 以 二氯甲烷 为溶剂， 以95%的产率得到3,3,7-trimethyl-4-triethylsilyloxytrideca-7,12-dienal
  参考文献：
  名称：

  Synthetic Studies toward Jatrophane Diterpenes from Euphorbia characias. Enantioselective Synthesis of (−)-15-O-Acetyl-3-O-propionyl-17-norcharaciol

  摘要：

  The enantioselective synthesis of (+)-17-norcharaciol is described. An uncatalyzed intramolecular carbonyl-ene reaction and a ring-closing metathesis were used as key C/C-connecting transformations to assemble the trans-bicyclo[10.3.0]pentadecane norditerpenoid core. We also report the evolution of our synthetic strategy toward the fully substituted characiol skeleton and the experiences from this venture.

  DOI：

  10.1021/jo802581g
• 作为产物：
  描述：

  C₂₂H₄₈O₃Si₂ 、 hex-5-enyl-triphenyl-phosphonium iodide 在 sodium hydride 作用下， 以 二甲基亚砜 为溶剂， 反应 1.5h， 以92%的产率得到triethyl-(3,3,7-trimethyl-4-triethylsilyloxytrideca-7,12-dienoxy)silane
  参考文献：
  名称：

  Synthetic Studies toward Jatrophane Diterpenes from Euphorbia characias. Enantioselective Synthesis of (−)-15-O-Acetyl-3-O-propionyl-17-norcharaciol

  摘要：

  The enantioselective synthesis of (+)-17-norcharaciol is described. An uncatalyzed intramolecular carbonyl-ene reaction and a ring-closing metathesis were used as key C/C-connecting transformations to assemble the trans-bicyclo[10.3.0]pentadecane norditerpenoid core. We also report the evolution of our synthetic strategy toward the fully substituted characiol skeleton and the experiences from this venture.

  DOI：

  10.1021/jo802581g