4-[(9,10-Dihydro-9-oxo-2-acridinyl)amino]-4-oxobutanoic acid | 477865-77-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-[(9,10-Dihydro-9-oxo-2-acridinyl)amino]-4-oxobutanoic acid
• 英文别名: 4-oxo-4-[(9-oxo-10H-acridin-2-yl)amino]butanoic acid
• CAS: 477865-77-3
• 化学式: C₁₇H₁₄N₂O₄
• 分子量: 310.3
• InChiKey: JKBCCRUCZWBPFN-UHFFFAOYSA-N

物化性质

• 沸点：
  638.0±55.0 °C(Predicted)
• 密度：
  1.414±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  95.5
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• ACRIDONE DERIVATIVES AS LABELS FOR FLUORESCENCE DETECTION OF TARGET MATERIALS
  申请人：SMITH JOHN ANTHONY

  公开号：US20080139788A1

  公开（公告）日：2008-06-12

  Disclosed are new acridone dye derivatives having characteristic fluorescence lifetimes. Also disclosed are methods for labelling target biological materials employing the acridone dyes and use of the labelled materials in biological assays. The acridone derivatives have the following structure: in which Z 1 and Z 2 represent the atoms necessary to complete one ring, two fused ring, or three fused ring aromatic or heteroaromatic systems, each ring having five or six atoms selected from carbon atoms and optionally no more than two atoms selected from oxygen, nitrogen and sulphur; R 2 , R 3 , R 4 and R 5 are selected from hydrogen, halogen, amide, hydroxyl, cyano, nitro, mono- or di-nitro-substituted benzyl, amino, mono- or di-C 1 -C 4 alkyl-substituted amino, sulphydryl, carbonyl, carboxyl, C 1 -C 6 alkoxy, acrylate, vinyl, styryl, aryl, heteroaryl, C 1 -C 20 alkyl, aralkyl, sulphonate, sulphonic acid, quaternary ammonium, the group -E-F and the group —(CH 2 —) n Y; R 1 is selected from hydrogen, mono- or di-nitro-substituted benzyl, C 1 -C 20 alkyl, aralkyl, the group -E-F and the group —(CH 2 —) n Y; where E is a spacer group, F is a target bonding group; Y is selected from sulphonate, sulphate, phosphonate, phosphate, quaternary ammonium and carboxyl; and n is an integer from 1 to 6. The invention also relates to a set of different fluorescent acridone dye derivatives, each dye having a different fluorescence lifetime, the set of dyes being particularly useful for multiparameter analysis.

  本发明涉及具有特征荧光寿命的新蒽醌染料衍生物。本发明还涉及使用蒽醌染料标记目标生物材料的方法以及标记材料在生物测定中的应用。蒽醌衍生物具有以下结构：其中Z1和Z2代表必要的原子以完成一个环，两个融合环或三个融合环的芳香或杂芳香系统，每个环具有从碳原子中选择的五个或六个原子以及最多从氧，氮和硫中选择的两个原子；R2，R3，R4和R5选择自氢，卤素，酰胺，羟基，氰基，硝基，单取代或双取代苯甲基，氨基，单取代或双取代C1-C4烷基取代的氨基，巯基，羰基，羧基，C1-C6烷氧基，丙烯酸酯，乙烯基，苯乙烯基，芳基，杂芳基，C1-C20烷基，芳基烷基，磺酸盐，磺酸，季铵盐，-E-F基团和-(CH2-)nY基团；R1选择自氢，单取代或双取代苯甲基，C1-C20烷基，芳基烷基，-E-F基团和-( -)nY基团；其中E是一个间隔基团，F是一个目标键合基团；Y选择自磺酸盐，硫酸盐，膦酸盐，磷酸盐，季铵盐和羧基；n是1到6的整数。本发明还涉及一组不同荧光蒽醌染料衍生物，每种染料具有不同的荧光寿命，该染料组合特别适用于多参数分析。
• US8034558B2
  申请人：——

  公开号：US8034558B2

  公开（公告）日：2011-10-11