1-(5-O-acetylnaphthyl)-2,3,4-tri-O-acetyl-β-D-xylopyranoside | 1155676-53-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(5-O-acetylnaphthyl)-2,3,4-tri-O-acetyl-β-D-xylopyranoside
• 英文别名: [(3R,4S,5R,6S)-4,5-diacetyloxy-6-(5-acetyloxynaphthalen-1-yl)oxyoxan-3-yl] acetate
• CAS: 1155676-53-1
• 化学式: C₂₃H₂₄O₁₀
• 分子量: 460.438
• InChiKey: JVVXSZDKRIVZRF-ACESQOTJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  124
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  乙酸酐 、 1-(5-hydroxynaphthyl)-β-D-xylopyranoside 在 吡啶 作用下， 以100%的产率得到1-(5-O-acetylnaphthyl)-2,3,4-tri-O-acetyl-β-D-xylopyranoside
  参考文献：
  名称：

  Antiproliferative effects of peracetylated naphthoxylosides

  摘要：

  The antiproliferative activity, and the capability of priming of glycosaminoglycan chains, of two series of peracetylated mono- and bis-xylosylated dihydroxynaphthalenes have been investigated for normal HFL-1 cells, as well as transformed T24 cells, and compared to the unprotected analogs. Our data show increased antiproliferative activity upon peracetylation, but a loss of selectivity towards T24 cells. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.01.065