6-methoxy-1-(3-(trimethoxysilyl)propyl)quinolinium bromide | 1363721-69-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-methoxy-1-(3-(trimethoxysilyl)propyl)quinolinium bromide
• CAS: 1363721-69-0
• 化学式: Br*C₁₆H₂₄NO₄Si
• 分子量: 402.36
• InChiKey: VHPWAOHYHNVCMW-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.59
• 重原子数：
  23.0
• 可旋转键数：
  8.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  40.8
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  6-甲氧基喹啉 、 3-溴丙基三甲氧基硅烷 反应 24.0h， 以86%的产率得到6-methoxy-1-(3-(trimethoxysilyl)propyl)quinolinium bromide
  参考文献：
  名称：

  A Cell-Penetrating Ratiometric Nanoprobe for Intracellular Chloride

  摘要：

  NanoChlor, a nanoparticle-based fluorescent probe for chloride that is both ratiometric and capable of spontaneously penetrating neuronal cells at submillimolar concentrations, was designed and studied. NanoChlor is built on silica nanoparticles grafted with 6-methoxyquinolinium as the chloride-sensitive component and fluorescein as the reference dye. A Stern-Volmer constant of 50 M-1 was measured in Ringer's buffer at pH 7.2, and the response to chemically induced chloride currents was recorded in real time in hippocampal cells.

  DOI：

  10.1021/ol300086w