N,N'-diacetyl-N,N'-di-(2-hydroxyphenyl)-6^A-amino-6^A6^D-deoxy-β-cyclodextrin | 1394345-41-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N,N'-diacetyl-N,N'-di-(2-hydroxyphenyl)-6^A-amino-6^A6^D-deoxy-β-cyclodextrin
• CAS: 1394345-41-5
• 化学式: C₅₈H₈₄N₂O₃₇
• 分子量: 1401.3
• InChiKey: RHSYTRBAKKAJPW-PRAUPJRVSA-N

反应信息

• 作为产物：
  描述：

  N,N'-diacetyl-N,N'-di-(2-hydroxyphenyl)-6^A-amino-6^A6^D-deoxy-2^A-G,3^A-G,6^B,C,E,F,G-nonadecakis-O-benzyl-β-cyclodextrin 在 palladium 10% on activated carbon 、 氢气 、 三氟乙酸 作用下， 以 乙二醇甲醚 为溶剂， 反应 48.0h， 以91%的产率得到N,N'-diacetyl-N,N'-di-(2-hydroxyphenyl)-6^A-amino-6^A6^D-deoxy-β-cyclodextrin
  参考文献：
  名称：

  Artificial enzymes based on cyclodextrin with phenol as the catalytic group

  摘要：

  beta-Cyclodextrin containing one or two N-linked ortho-N-acetylaminophenols has been synthesized and tested for their properties as artificial glycosidases. Four different para-nitrophenyl glycosides were used as substrates and k(cat)/k(uncat) values of up to 381 were found for the di-functionalized products, whereas the mono derivative showed up to 47 times rate enhancement. The optimum pH for the catalysis was found to be approximately pH 8 and the influence of phosphate concentration was investigated. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.07.050
• 作为试剂：
  描述：

  4-硝基苯基-α-D-吡喃半乳糖苷 在 N,N'-diacetyl-N,N'-di-(2-hydroxyphenyl)-6^A-amino-6^A6^D-deoxy-β-cyclodextrin 作用下， 以 aq. phosphate buffer 为溶剂， 生成 对硝基苯酚
  参考文献：
  名称：

  Artificial enzymes based on cyclodextrin with phenol as the catalytic group

  摘要：

  beta-Cyclodextrin containing one or two N-linked ortho-N-acetylaminophenols has been synthesized and tested for their properties as artificial glycosidases. Four different para-nitrophenyl glycosides were used as substrates and k(cat)/k(uncat) values of up to 381 were found for the di-functionalized products, whereas the mono derivative showed up to 47 times rate enhancement. The optimum pH for the catalysis was found to be approximately pH 8 and the influence of phosphate concentration was investigated. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.07.050