9-methoxy-1',1',2',2'-tetramethylspiro[7H-benzo[7]annulene-6,3'-cyclopropane]-5-one | 1060767-48-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 9-methoxy-1',1',2',2'-tetramethylspiro[7H-benzo[7]annulene-6,3'-cyclopropane]-5-one
• CAS: 1060767-48-7
• 化学式: C₁₈H₂₂O₂
• 分子量: 270.371
• InChiKey: WDZVCSXVACVLTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  、 lithium 4-methoxy-1-naphtholate 以 四氢呋喃 为溶剂， 以26%的产率得到9-methoxy-1',1',2',2'-tetramethylspiro[7H-benzo[7]annulene-6,3'-cyclopropane]-5-one
  参考文献：
  名称：

  A novel synthesis of spiro[2.6]nonadienones by the reaction of magnesium cyclopropylidenes with naphtholates and phenolates

  摘要：

  The sulfoxide-magnesium exchange reaction of aryl 1-chlorocyclopropyl sulfoxides with i-PrMgCl in THF at low temperature gave magnesium cyclopropylidenes. Treatment of the magnesium cyclopropylidenes with lithium naphtholates or phenolates resulted in the formation of spiro[2.6]nonadienones in up to 82% yield. The structure of the spiro[2.6]nonadienones was found to be dependent on the structure of the naphtholates and phenolates. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.07.066

文献信息

• A novel synthesis of spiro[2.6]nonadienones by the reaction of magnesium cyclopropylidenes with naphtholates and phenolates
  作者：Tsuyoshi Satoh、Shinobu Nagamoto、Masanobu Yajima、Yukie Yamada、Yuki Ohata、Makoto Tadokoro

  DOI：10.1016/j.tetlet.2008.07.066

  日期：2008.9

  The sulfoxide-magnesium exchange reaction of aryl 1-chlorocyclopropyl sulfoxides with i-PrMgCl in THF at low temperature gave magnesium cyclopropylidenes. Treatment of the magnesium cyclopropylidenes with lithium naphtholates or phenolates resulted in the formation of spiro[2.6]nonadienones in up to 82% yield. The structure of the spiro[2.6]nonadienones was found to be dependent on the structure of the naphtholates and phenolates. (c) 2008 Elsevier Ltd. All rights reserved.