(E)-2-(4-fluorobenzoxy)-3-prenyl-4-methoxy-N-(2-aminophenyl)cinnamide | 1246952-30-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-2-(4-fluorobenzoxy)-3-prenyl-4-methoxy-N-(2-aminophenyl)cinnamide
• 英文别名: (E)-2-(4-fluorobenzoxy)-3-prenyl-4-methoxy-N-(2-aminophenyl)cinnamamide；(E)-N-(2-aminophenyl)-3-[2-[(4-fluorophenyl)methoxy]-4-methoxy-3-(3-methylbut-2-enyl)phenyl]prop-2-enamide
• CAS: 1246952-30-6
• 化学式: C₂₈H₂₉FN₂O₃
• 分子量: 460.548
• InChiKey: WVVXKTBDXWIUAM-SFQUDFHCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  73.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• CINAMIC COMPOUNDS AND DERIVATIVES THEREFROM FOR THE INHIBITION OF HISTONE DEACETYLASE
  申请人：Huang Chung-Yang

  公开号：US20100256401A1

  公开（公告）日：2010-10-07

  The invention relates to a compound represented by the following formula (I): and pharmaceutically acceptable salts, stereoisomers, enantiomers, prodrugs and solvates thereof. The compounds are useful as an agent for enhancing the neurite outgrowth and preventing or treating of diseases associated with HDAC in particular, tumor or cell proliferative diseases. In particular, the compounds of the invention can be used as an agent for anti-cancer, anti-diabetic, and anti-neurodegenerative diseases such as Alzheimer's disease, Huntington's disease, Spinocerebellar Ataxias (SCA), and human spinal muscular atrophy (SMA).

  该发明涉及以下式(I)所表示的化合物及其药学上可接受的盐、立体异构体、对映异构体、前药和溶剂合物。这些化合物可用作增强神经突起生长的药剂，并预防或治疗与HDAC特别相关的疾病，如肿瘤或细胞增殖性疾病。具体来说，该发明的化合物可用作抗癌、抗糖尿病和抗神经退行性疾病的药剂，如阿尔茨海默病、亨廷顿病、脊髓小脑共济失调（SCA）和人类脊髓肌肉萎缩症（SMA）的药剂。
• Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase
  申请人：NatureWise Biotech & Medicals Corporation

  公开号：EP2236503A1

  公开（公告）日：2010-10-06

  The invention relates to a compound represented by the following formula (I): and pharmaceutically acceptable salts, stereoisomers, enantiomers, prodrugs and solvates thereof. The compounds are useful as an agent for enhancing the neurite outgrowth and preventing or treating of diseases associated with HDAC in particular, tumor or cell proliferative diseases. In particular, the compounds of the invention can be used as an agent for anti-cancer, anti-diabetic, and anti-neurodegenerative diseases such as Alzheimer's disease, Huntington's disease, Spinocerebellar Ataxias (SCA), and human spinal muscular atrophy (SMA).

  本发明涉及一种由下式 (I) 代表的化合物： 及其药学上可接受的盐、立体异构体、对映体、原药和溶液。这些化合物可用于增强神经元的生长，预防或治疗与 HDAC 相关的疾病，尤其是肿瘤或细胞增殖性疾病。特别是，本发明的化合物可用作抗癌、抗糖尿病和抗神经退行性疾病的药物，如阿尔茨海默病、亨廷顿病、脊髓小脑共济失调（SCA）和人类脊髓性肌萎缩症（SMA）。
• New use of histone deacetylase inhibitors in changing MRJP3 protein in royal jelly
  申请人：NatureWise Biotech & Medicals Corporation

  公开号：EP2277387A1

  公开（公告）日：2011-01-26

  The invention provides a method of changing a ratio of 68 to 64 kDa protein of MRJP3 in a royal jelly, a method of producing a royal jelly comprising MRJP3 having a changed ratio of 68 to 64 kDa protein relative to a control royal jelly and the royal jelly produced thereform. Also provided is a method of promoting the growth of the larva of a queen bee comprising feeding the larva of the queen bee a royal jelly of the invention. Further provided is a method of producing bee larva, pupa and queen bees with sizes larger than normal.

  本发明提供了一种改变蜂王浆中MRJP3的68与64 kDa蛋白比例的方法，一种生产含有MRJP3的蜂王浆的方法，相对于对照蜂王浆，MRJP3的68与64 kDa蛋白比例发生了改变，并以这种方法生产出蜂王浆。还提供了一种促进蜂王幼虫生长的方法，包括给蜂王幼虫喂食本发明的蜂王浆。此外，还提供了一种生产蜂王幼虫、蛹和蜂王的方法，其蜂王幼虫、蛹和蜂王的尺寸大于正常尺寸。
• NEW USE OF HISTONE DEACETYLASE INHIBITORS IN CHANGING MRJP3 PROTEIN IN ROYAL JELLY
  申请人：NatureWise Biotech & Medicals Corporation

  公开号：EP2277387B1

  公开（公告）日：2016-10-19
• USE OF HISTONE DEACETYLASE INHIBITORS IN CHANGING MRJP3 PROTEIN IN ROYAL JELLY
  申请人：NATUREWISE BIOTECH & MEDICALS CORPORATION

  公开号：US20140288166A1

  公开（公告）日：2014-09-25

  The invention provides a method of changing a ratio of 68 to 64 kDa protein of MRJP3 in a royal jelly, a method of producing a royal jelly comprising MRJP3 having a changed ratio of 68 to 64 kDa protein relative to a control royal jelly and the royal jelly produced thereform. Also provided is a method of promoting the growth of the larva of a queen bee comprising feeding the larva of the queen bee a royal jelly of the invention. Further provided is a method of producing bee larva, pupa and queen bees with sizes larger than normal.