2-Methyl-4-aethyl-8-methoxy-chinolin | 91956-71-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-Methyl-4-aethyl-8-methoxy-chinolin
• 英文别名: 4-Ethyl-8-methoxy-2-methylquinoline
• CAS: 91956-71-7
• 化学式: C₁₃H₁₅NO
• 分子量: 201.268
• InChiKey: JYGMZKCNRNKSOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS
  申请人：Bergmann John E.

  公开号：US20110021509A1

  公开（公告）日：2011-01-27

  Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological disorders such as Parkinson's disease, Huntington's disease, Alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, Bell's palsy, cerebral palsy, sleep disorders, pain, Tourette syndrome, schizophrenia, delusional disorders, drug-induced psychosis and panic and obsessive-compulsive disorders. The compounds have the general structure: wherein m, n, p, x, R, R 1 , R 2 , R 3 , R 4 , R 5 , A and B, are defined herein, including pharmaceutically acceptable salts, stereoisomers, solvates or prodrugs thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for inhibiting PDE10 in a warm-blooded animal in need of the same.

  本发明披露了抑制PDE10的化合物，可用于治疗多种疾病，包括（但不限于）精神病、焦虑、运动障碍和/或神经系统疾病，如帕金森病、亨廷顿病、阿尔茨海默病、脑炎、恐惧症、癫痫、失语症、贝尔氏麻痹、脑瘫、睡眠障碍、疼痛、抽动症、精神分裂症、妄想症、药物诱导的精神病、惊恐障碍和强迫症。这些化合物具有以下一般结构：其中m、n、p、x、R、R1、R2、R3、R4、R5、A和B在本文中有定义，包括药学上可接受的盐、立体异构体、溶剂化物或其前药。本发明还披露了含有本发明化合物与药学上可接受的载体组合的组合物，以及与使用本发明化合物抑制温血动物中的PDE10有关的方法。
• US8278327B2
  申请人：——

  公开号：US8278327B2

  公开（公告）日：2012-10-02