9-(4-methoxyphenyl)-4-methyl-7-tosyl-7,8-dihydro-4,7-phenanthrolin-3(4H)-one | 1629780-42-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9-(4-methoxyphenyl)-4-methyl-7-tosyl-7,8-dihydro-4,7-phenanthrolin-3(4H)-one
• 英文别名: 10-(4-methoxyphenyl)-4-methyl-7-(4-methylphenyl)sulfonyl-8H-4,7-phenanthrolin-3-one
• CAS: 1629780-42-2
• 化学式: C₂₇H₂₄N₂O₄S
• 分子量: 472.565
• InChiKey: NCFKUCQKJWHFKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  75.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-[3-(4-methoxyphenyl)prop-2-ynyl]-4-methyl-N-(1-methyl-2-oxoquinolin-6-yl)benzenesulfonamide 在 iron(III) chloride 作用下， 以 乙腈 为溶剂， 反应 12.0h， 以63%的产率得到9-(4-methoxyphenyl)-4-methyl-7-tosyl-7,8-dihydro-4,7-phenanthrolin-3(4H)-one
  参考文献：
  名称：

  Regioselective Synthesis of Dihydropyridocoumarin and Phenanthrolinone Derivatives­ via Iron(III) Chloride Mediated Intramolecular Cyclization

  摘要：

  Potentially bioactive angular dihydropyridocoumarin and phenanthrolinone derivatives are synthesized in good to excellent yields using readily available iron(III) chloride (FeCl3) as the catalyst. The process is very simple, straightforward and inexpensive, and provides a diverse range of pyranoquinolone or phenanthrolinone derivatives, via a 6-endo-dig mode of cyclization, starting from simple and easily available 6-(N-propargyl) aminocoumarin and -quinolone derivatives.

  DOI：

  10.1055/s-0033-1340902

文献信息

• Regioselective Synthesis of Dihydropyridocoumarin and Phenanthrolinone Derivatives­ via Iron(III) Chloride Mediated Intramolecular Cyclization
  作者：K. Majumdar、Sudipta Ponra

  DOI：10.1055/s-0033-1340902

  日期：——

  Potentially bioactive angular dihydropyridocoumarin and phenanthrolinone derivatives are synthesized in good to excellent yields using readily available iron(III) chloride (FeCl3) as the catalyst. The process is very simple, straightforward and inexpensive, and provides a diverse range of pyranoquinolone or phenanthrolinone derivatives, via a 6-endo-dig mode of cyclization, starting from simple and easily available 6-(N-propargyl) aminocoumarin and -quinolone derivatives.