6-benzoyl-4-hydroxy-2-oxo-1H-pyridine-3-carboxylic acid | 1228555-64-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-benzoyl-4-hydroxy-2-oxo-1H-pyridine-3-carboxylic acid
• CAS: 1228555-64-3
• 化学式: C₁₃H₉NO₅
• 分子量: 259.218
• InChiKey: SIENWKXICLEMEA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-benzoyl-4-hydroxy-2-oxo-1H-pyridine-3-carboxylic acid 在 sodium tetrahydroborate 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 1.0h， 生成 4-hydroxy-6-(hydroxy(phenyl)methyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid
  参考文献：
  名称：

  The first total synthesis of potent human chymase inhibitor SPF32629B via regioselective bromination and O-acylation strategy

  摘要：

  An efficient total synthesis of (+/-)-SPF32629B is described. The key features of the synthesis include regioselective bromination followed by carboxylation at C-3 and protecting-group-free regioselective acylation of hydroxyl group present at C7. Structure was determined by X-ray analysis. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.03.091
• 作为产物：
  描述：

  methyl 6-benzoyl-4-hydroxy-2-oxo-1H-pyridine-3-carboxylate 在 lithium hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 36.0h， 生成 6-benzoyl-4-hydroxy-2-oxo-1H-pyridine-3-carboxylic acid
  参考文献：
  名称：

  The first total synthesis of potent human chymase inhibitor SPF32629B via regioselective bromination and O-acylation strategy

  摘要：

  An efficient total synthesis of (+/-)-SPF32629B is described. The key features of the synthesis include regioselective bromination followed by carboxylation at C-3 and protecting-group-free regioselective acylation of hydroxyl group present at C7. Structure was determined by X-ray analysis. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.03.091

文献信息

• SPF32629A and SPF32629B: Enantioselective synthesis, determination of absolute configuration, cytotoxicity and antibacterial evaluation
  作者：Srinivasa Rao Vegi、Shanthaveerappa K. Boovanahalli、Balaram Patro、K. Mukkanti

  DOI：10.1016/j.ejmech.2011.02.039

  日期：2011.5

  We report herein an efficient enantioselective synthesis of SPF32629A and SPF32629B through one-pot enantioselective reduction and protecting-group-free regioselective O-acylation strategy. The absolute configuration of the enantiomerically pure isomers was established by Mosher ester analysis. The inhibitory potencies of the synthesized compounds were assayed in vitro against a panel of microorganisms and against A549 human lung adenocarcinoma cell line. Compounds 2, 11 and 12 displayed moderate to potent antibacterial activity against all the tested strains and compounds 7, 8, 2, 11 and 12 exhibited significant cytotoxicity in a dose-dependent manner with an IC50 values ranging from 2.92 to 4.14 mu g/ml and 8-11 mu M. (C) 2011 Elsevier Masson SAS. All rights reserved.