5-(3,5-dichloropyridin-4-ylamino)-8,8-dimethyl-3-(pyridin-3-ylmethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c]isoquinolin-1-ol | 1242065-34-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-(3,5-dichloropyridin-4-ylamino)-8,8-dimethyl-3-(pyridin-3-ylmethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c]isoquinolin-1-ol
• 英文别名: 5-[(3,5-Dichloropyridin-4-yl)amino]-8,8-dimethyl-3-(pyridin-3-ylmethyl)-2,6,7,9-tetrahydropyrazolo[3,4-c]isoquinolin-1-one
• CAS: 1242065-34-4
• 化学式: C₂₃H₂₂Cl₂N₆O
• 分子量: 469.373
• InChiKey: JOGFCCJPNMNQIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  83
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] NEW TETRAHYDROPYRAZOLO[3,4-C]ISOQUINOLIN-5-AMINE DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS TÉTRAHYDROPYRAZOLO[3,4-C]ISOQUINOLIN-5-AMINE
  申请人：ALMIRALL SA

  公开号：WO2010097172A1

  公开（公告）日：2010-09-02

  New tetrahydropyrazolo[3,4-c]isoquinolin-5-amine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of the phosphodiesterase IV (PDE4).

  揭示了具有化学结构式(I)的新四氢吡唑并[3,4-c]异喹啉-5-胺衍生物；以及它们的制备方法、包含它们的药物组合物和它们作为磷酸二酯酶IV（PDE4）抑制剂在治疗中的用途。
• New tetrahydropyrazolo[3,4-c]isoquinolin-5-amine derivatives
  申请人：Almirall, S.A.

  公开号：EP2226323A1

  公开（公告）日：2010-09-08

  New tetrahydropyrazolo[3,4-c]isoquinolin-5-amine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of the phosphodiesterase IV (PDE4).

  本研究公开了具有式（I）化学结构的新的四氢吡唑并[3,4-c]异喹啉-5-胺衍生物，以及它们的制备工艺、包含它们的药物组合物和它们在治疗中作为磷酸二酯酶 IV (PDE4) 抑制剂的用途。